| Texto completo | |
| Autor(es): Mostrar menos - |
Curiati, P. K.
[1]
;
Tamashiro, J. H.
[1, 2]
;
Squarzoni, P.
[1]
;
Duran, F. L. S.
[1]
;
Santos, L. C.
[1]
;
Wajngarten, M.
[3]
;
Leite, C. C.
[4]
;
Vallada, H.
[1]
;
Menezes, P. R.
[5, 6]
;
Scazufca, M.
[7, 6]
;
Busatto, G. F.
[1]
;
Alves, T. C. T. F.
[1, 2]
Número total de Autores: 12
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Sch Med, Neuroimaging Psychiat Lab, Dept Psychiat, LIM 21, BR-05403010 Sao Paulo - Brazil
[2] ABC Reg Med Sch, Dept Psychiat, Sando Andre - Brazil
[3] Univ Sao Paulo, Sch Med, Div Cardiogeriatr, Inst Heart, BR-05403010 Sao Paulo - Brazil
[4] Univ Sao Paulo, Sch Med, Dept Radiol, BR-05403010 Sao Paulo - Brazil
[5] Univ Sao Paulo, Sch Med, Dept Prevent Med, BR-05403010 Sao Paulo - Brazil
[6] Univ Sao Paulo, Univ Hosp, Epidemiol Sect, BR-05403010 Sao Paulo - Brazil
[7] Univ Sao Paulo, Sch Med, Clin Hosp, Dept Psychiat, LIM 23, BR-05403010 Sao Paulo - Brazil
Número total de Afiliações: 7
|
| Tipo de documento: | Artigo Científico |
| Fonte: | AMERICAN JOURNAL OF NEURORADIOLOGY; v. 30, n. 10, p. 1850-1856, NOV-DEC 2009. |
| Citações Web of Science: | 39 |
| Resumo | |
BACKGROUND AND PURPOSE: Several morphometric MR imaging studies have investigated age- and sex-related cerebral volume changes in healthy human brains, most often by using samples spanning several decades of life and linear correlation methods. This study aimed to map the normal pattern of regional age-related volumetric reductions specifically in the elderly population. MATERIALS AND METHODS: One hundred thirty-two eligible individuals (67-75 years of age) were selected from a community-based sample recruited for the Sao Paulo Ageing and Health (SPAH) study, and a cross-sectional MR imaging investigation was performed concurrently with the second SPAH wave. We used voxel-based morphometry (VBM) to conduct a voxelwise search for significant linear correlations between gray matter (GM) volumes and age. In addition, region-of-interest masks were used to investigate whether the relationship between regional GM (rGM) volumes and age would be best predicted by a nonlinear model. RESULTS: VBM and region-of-interest analyses revealed selective foci of accelerated rGM loss exclusively in men, involving the temporal neocortex, prefrontal cortex, and medial temporal region. The only structure in which GM volumetric changes were best predicted by a nonlinear model was the left parahippocampal gyrus. CONCLUSIONS: The variable patterns of age-related GM loss across separate neocortical and temporolimbic regions highlight the complexity of degenerative processes that affect the healthy human brain across the life span. The detection of age-related Ill GM decrease in men supports the view that atrophy in such regions should be seen as compatible with normal aging. (AU) | |
| Processo FAPESP: | 04/15336-5 - Alterações cerebrais associadas a fatores de risco cardiovascular: um estudo de base populacional usando morfometria voxel-a-voxel por ressonância magnética e medidas de metabolismo de glicose por tomografia por emissão de pósitrons |
| Beneficiário: | Geraldo Busatto Filho |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 06/04405-1 - Alteracoes de ressonancia magnetica cerebral relacionadas ao envelhecimento: medidas de substancias branca e cinzenta mensuradas por morfometria voxel a voxel em idosos saudaveis. |
| Beneficiário: | Pedro Kallas Curiati |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |
| Processo FAPESP: | 04/12694-8 - Incidência de demência e declínio cognitivo em idosos de baixa renda em São Paulo: estudo de coorte |
| Beneficiário: | Isabela Judith Martins Bensenor |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |