Increased Immunoglobulin G Anti-Paracoccidioides brasiliensis Serum Antibody Avidity as a Predictor of Favorable Posttherapeutic Evolution in Paracoccidioidomycosis

Autor(es)

Yoshida, Marcia ^{[1, 2]} ; Arroyo Sanchez, Maria Carmen ^[3] ; Shikanai-Yasuda, Maria Aparecida ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Med, Hosp Clin, Dept Molestias Infecciosas & Parasitarias, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Fac Med, Hosp Clin, LIM 48, Sao Paulo - Brazil

^[3] Inst Trop Med, Lab Soroepidemiol & Imunobiol, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Clinical and Vaccine Immunology; v. 16, n. 11, p. 1583-1586, NOV 2009.
• Citações Web of Science: 1

Resumo

Paracoccidioidomycosis is endemic in Latin America, and ca. 80% of all cases occur in Brazil. Little is known about antibody avidity or the evolution of such avidity in the posttherapeutic period for the different clinical presentations of the disease. In the present study, we evaluated 53 patients with paracoccidioidomycosis and calculated the avidity index. Medium-and high-avidity antibodies were found in 79.5% of patients with chronic presentation (n = 39). Among patients with the acute form (n = 14), 57.1% of the antibodies presented low avidity. In the posttherapeutic period, there was a significant increase in antibody avidity in patients presenting with the chronic multifocal form. In our preliminary study, which needs to be confirmed using a larger number of samples, the optimized method for studying antibody avidity detected differences among the clinical presentations of the mycosis and indicated the value of the avidity index as a marker of posttherapeutic evolution of patients with a multifocal chronic form of the disease. (AU)

• Processo FAPESP: 02/06481-6 - Reconhecimento de peptídeos da GP 43 por Linfócitos T de pacientes com diferentes formas clínicas de paracoccidioidomicose: relação com haplótipos de HLA (antígeno leucocitário humano) e gravidade das formas clínicas
• Beneficiário: Maria Aparecida Shikanai Yasuda
• Modalidade de apoio: Auxílio à Pesquisa - Regular