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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Nuclear morphometry in cytopathology: a prognostic indicator for canine cutaneous mast cell tumors

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Autor(es):
Strefezzi, Ricardo De Francisco [1, 2] ; Xavier, Jose Guilherme [3, 4] ; Kleeb, Silvia Regina [4] ; Catao-Dias, Jose Luiz [2]
Número total de Autores: 4
Afiliação do(s) autor(es):
[1] Univ Bandeirante Sao Paulo, Sao Paulo - Brazil
[2] Univ Sao Paulo, Fac Med Vet & Zootecnia, Dept Patol, Sao Paulo - Brazil
[3] Univ Paulista, Sao Paulo - Brazil
[4] Univ Metodista Sao Paulo, Sao Paulo - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION; v. 21, n. 6, p. 821-825, NOV 2009.
Citações Web of Science: 15
Resumo

Twenty-nine canine cutaneous mast cell tumors (MCTs) were morphometrically analyzed with regard to mean nuclear area (MNA) using cytopathology smears. The results showed a correlation between MNA and survival. When graded into 2 morphometrically different groups, there were statistically significant differences among high- and low-grade MCTs, regarding both Romanowsky-type stain and hematoxylin and eosin. Cytomorphometry could also separate histologic grade II tumors with better prognosis from the more aggressive MCTs. The results indicated that nuclear morphometry on cytopathology preparations can predict the biological behavior of cutaneous MCTs in dogs in an independent manner, yielding a rapid and reproducible diagnosis, which renders the method useful for veterinary oncology. (AU)

Processo FAPESP: 05/50407-3 - Indicadores prognósticos para mastocitomas: estudo morfométrico e imunoistoquímico
Beneficiário:Jose Luiz Catao Dias
Modalidade de apoio: Auxílio à Pesquisa - Regular