| Texto completo | |
| Autor(es): |
Mussi-Pinhata, Marisa M.
[1]
;
Yamamoto, Aparecida Y.
[1]
;
Brito, Rosangela M. Moura
[1]
;
Isaac, Myriam de Lima
[2]
;
de Carvalho e Oliveira, Patricia F.
[1]
;
Boppana, Suresh
[3, 4]
;
Britt, William J.
[3, 5, 4]
Número total de Autores: 7
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Pediat, Sao Paulo - Brazil
[2] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Ophtalmol Otolaryngol Head & Neck Surg, Sao Paulo - Brazil
[3] Univ Alabama, Sch Med, Dept Pediat, Birmingham, AL - USA
[4] Univ Alabama, Sch Med, Dept Microbiol, Birmingham, AL - USA
[5] Univ Alabama, Sch Med, Dept Neurobiol, Birmingham, AL - USA
Número total de Afiliações: 5
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Clinical Infectious Diseases; v. 49, n. 4, p. 522-528, AUG 15 2009. |
| Citações Web of Science: | 122 |
| Resumo | |
Background. The natural history of congenital cytomegalovirus (CMV) infection is scarcely known in populations with high maternal CMV seroprevalence. This study evaluated the birth prevalence, clinical findings at birth, and hearing outcome in CMV-infected children from such a population. Methods. Consecutively born infants were screened for the presence of CMV in urine and/or saliva specimens during the first 2 weeks after birth. Neonatal clinical findings were recorded, and CMV-infected children were tested to document hearing function during follow-up. A subset of mothers of CMV-infected infants were prenatally tested for the presence of anti-CMV immunoglobulin G antibodies. Results. Congenital CMV infection was confirmed in 87 (1.08%; 95% confidence interval {[}CI], 0.86%-1.33%) of 8047 infants. Seven infants (8.1%; 95% CI, 3.3%-15.9%) had at least 1 clinical finding suggestive of CMV infection, and 4 (4.6%; 95% CI, 1.3%-11.3%) had 13 findings of systemic disease. Sensorineural hearing loss was found in 5 (8.6%; 95% CI, 2.9%-19.0%) of 58 children tested at a median age of 21 months. Bilateral profound hearing loss was observed in 2 children, and the hearing threshold was 160 decibels in all 5 children with hearing loss, including 2 children born to mothers with probable nonprimary CMV infection. Conclusions. The results of this large newborn screening study in a population with high CMV seroimmunity provide additional evidence that congenital CMV disease occurs in populations with high seroprevalence rates, with a similar incidence of CMV-related hearing loss to that reported in the offspring of women from populations in developed countries with lower rates of seroimmunity to CMV. (AU) | |
| Processo FAPESP: | 02/04166-6 - Infecção congênita por citomegalovírus em população com elevada soropositividade: caracterização molecular das cepas virais e avaliação da ocorrência de reinfecção materna |
| Beneficiário: | Aparecida Yulie Yamamoto |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |