Effect of remifentanil hydrochloride administered via constant rate infusion on the minimum alveolar concentration of isoflurane in cats

Autor(es)

Ferreira, Tatiana H. ^[1] ; Aguiar, Antonio J. A. ^[1] ; Valverde, Alexander ^[2] ; Neto, Francisco J. Teixeira ^[1] ; Steagall, Paulo V. M. ^[3] ; Soares, Joao H. N. ^[4]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo State, Sch Vet Med & Anim Sci, Dept Vet Surg & Anesthesiol, BR-18618000 Botucatu, SP - Brazil

^[2] Univ Guelph, Ontario Vet Coll, Dept Clin Studies Anesthesiol, Guelph, ON N1G 2W1 - Canada

^[3] Univ Wisconsin, Madison Sch Vet Med, Dept Surg Sci, Madison, WI 53706 - USA

^[4] Univ Fed Rio de Janeiro, COPPE, Biomed Engn Program, BR-21941914 Rio De Janeiro - Brazil

• Tipo de documento: Artigo Científico
• Fonte: AMERICAN JOURNAL OF VETERINARY RESEARCH; v. 70, n. 5, p. 581-588, MAY 2009.
• Citações Web of Science: 20

Resumo

Objective-To evaluate the effects of increasing doses of remifentanil hydrochloride administered via constant rate infusion (CRI) on the minimum alveolar concentration (MAC) of isoflurane in cats. Animals-6 healthy adult cats. Procedures-For each cat, 2 experiments were performed (2-week interval). On each study day, anesthesia was induced and maintained with isoflurane; a catheter was placed in a cephalic vein for the administration of lactated Ringer's solution or remifentanil CRIs, and a catheter was placed in the jugular vein for collection of blood samples for blood gas analyses. On the first study day, individual basal MAC (MAC(Basal)) was determined for each cat. On the second study day, 3 remifentanil CRIs (0.25, 0.5, and 1.0 mu g/kg/min) were administered (in ascending order); for each infusion, at least 30 minutes elapsed before determination of MAC (designated as MAC(R0.25') MAC(R0.5') and MACR(R1.0') respectively). A 15-minute washout period was allowed between CRIs. A control MAC (MAC Control) was determined after the last remifentanil infusion. Results-Mean +/- SD MAC(Basal) and MAC(Control) values at sea level did not differ significantly (1.66 +/- 0.08% and 1.52 +/- 0.21%, respectively). The MAC values determined for each remifentanil CRI did not differ significantly. However, MACR(0.25') MAC(R0.5') and MAC(R1.0) were significantly decreased, compared with MAC(Basal') by 23.4 +/- 79%, 29.8 +/- 8.3%, and 26.0 +/- 9.4%, respectively. Conclusions and Clinical Relevance-The 3 doses of remifentanil administered via CRI resulted in a similar degree of isoflurane MAC reduction in adult cats, indicating that a ceiling effect was achieved following administration of the lowest dose. (Am J Vet Res 2009;70:581-588) (AU)

• Processo FAPESP: 05/58005-1 - Efeitos do cloridrato remifentanil, administrado em infusão contínua, na concentração alveolar mínima (CAM) de isofluorano em felinos
• Beneficiário: Tatiana Henriques Ferreira
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 05/57662-9 - Alexander Valverde | University of Guelph - Canadá
• Beneficiário: Antonio José de Araujo Aguiar
• Modalidade de apoio: Auxílio à Pesquisa - Pesquisador Visitante - Internacional
• Processo FAPESP: 05/60025-0 - Efeitos do cloridrato de remifentanil, administrado em infusao continua, na concentracao alveolar minima (cam) de isofluorano em felinos.
• Beneficiário: Antonio José de Araujo Aguiar
• Modalidade de apoio: Auxílio à Pesquisa - Regular