| Texto completo | |
| Autor(es): |
Gornes, Sarnirah Abreu
[1]
;
dos Reis, Luciene Machado
[2]
;
Noronha, Irene Lourdes
[2]
;
Jorgetti, Vanda
[2]
;
Heilberg, Ita Pfeferman
[1]
Número total de Autores: 5
|
| Afiliação do(s) autor(es): | [1] Univ Fed Sao Paulo, Div Nephrol, BR-04023062 Sao Paulo - Brazil
[2] Univ Sao Paulo, Div Nephrol, Sao Paulo - Brazil
Número total de Afiliações: 2
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Clinical Journal of the American Society of Nephrology; v. 3, n. 5, p. 1446-1452, SEP 2008. |
| Citações Web of Science: | 14 |
| Resumo | |
Background and objectives: This study aimed to determine the expression of osteoprotegerin, receptor activator of nuclear factor kappa B ligand, interleukin-la, transforming growth factor-beta, and basic fibroblast growth factor in stone-forming patients with idiopathic hypercalciuria. Design, setting, participants, \& measurements: Immunohistochemical analysis was performed in undecalcified bone samples previously obtained from 36 transiliac bone biopsies of patients who had idiopathic hypercalciuria and whose histomorphometry had shown lower bone volume, increased bone resorption, and prolonged mineralization lag time. Results: Bone expression of receptor activator of nuclear factor kappa B ligand and osteoprotegerin was significantly higher in patients with idiopathic hypercalciuria versus control subjects. Transforming growth factor-beta immunostaining was lower in patients with idiopathic hypercalciuria than in control subjects and correlated directly with mineralization surface. Interleukin-la and basic fibroblast growth factor staining did not differ between groups. Receptor activator of nuclear factor kappa B ligand bone expression was significantly higher in patients who had idiopathic hypercalciuria and exhibited higher versus normal bone resorption. Conclusion: A higher expression of receptor activator of nuclear factor kappa B ligand in bone tissue suggests that increased bone resorption in patients with idiopathic hypercalciuria is mediated by receptor activator of nuclear factor kappa B ligand. Osteoprotegerin bone expression might have been secondarily increased in an attempt to counteract the actions of receptor activator of nuclear factor kappa B ligand. The low bone expression of transforming growth factor-beta could contribute to the delayed mineralization found in such patients. (AU) | |
| Processo FAPESP: | 03/09271-5 - Analise da expressao da osteoprotegerina, rank-l, rank e de outras citocinas em tecido osseo de pacientes com litiase renal. |
| Beneficiário: | Ita Pfeferman Heilberg |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 03/05652-4 - Análise da expressão de osteoprotegerina, RANKL e RANK em tecido ósseo de pacientes com litíase renal |
| Beneficiário: | Samirah Abreu Gomes |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |