Natural polymer-based magnetic hydrogels: Potential vectors for remote-controlled drug release

Autor(es)

Paulino, Alexandre T. ^{[1, 2, 3]} ; Pereira, Antonio G. B. ^[4] ; Fajardo, Andre R. ^[4] ; Erickson, Kristin ^[2] ; Kipper, Matt J. ^[2] ; Muniz, Edvani C. ^[4] ; Belfiore, Laurence A. ^[2] ; Tambourgi, Elias B. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Separat Proc Lab, Dept Chem Syst Engn, Sch Chem Engn, BR-13083852 Campinas, SP - Brazil

^[2] Colorado State Univ, Dept Chem & Biol Engn, Polymer Phys & Engn Lab, Ft Collins, CO 80523 - USA

^[3] Santa Catarina State Univ, Higher Educ Ctr W, Dept Food Engn, BR-89870000 Chapeco Pinhalzinho, SC - Brazil

^[4] GMPC UEM, Polymer Mat & Composite Lab, Dept Chem, BR-87050900 Maringa, Parana - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Carbohydrate Polymers; v. 90, n. 3, p. 1216-1225, OCT 15 2012.
• Citações Web of Science: 34

Resumo

The preparation and characterization of natural polymer-based hydrogels that contain 50-nm diameter magnetite (i.e., FeO:Fe2O3) nanoparticles are described herein. Fourier-transform infrared spectroscopy (FTIR) analysis confirmed the efficiency of the polysaccharide-modifying process. Thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), and compressive moduli demostrate that the presence of magnetite improves thermal and mechanical resistance. Transient diffusion of water in magnetic hydrogels was analyzed via boundary layer mass transfer across an expaning interface, and the degree of swelling of these polysaccharide hydrogels decreases in the presence of magnetite, with no variation in the binary diffusion mechanism. The absence of hysteresis loops and coercivity observed via magnetometry suggests that magnetic hydrogels are useful for remote-controlled drug release, as demonstrated by magnetic-field-induced release of curcumin. Experiments reveal that magnetic hydrogels with greater magnetic susceptibility have the potential to release larger concentrations of drugs from the hydrogel network. (c) 2012 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 08/00285-7 - Síntese de hidrogéis magnéticos constituídos de polissacarídeos para a aplicação na remediação de águas e efluentes industriais
• Beneficiário: Alexandre Tadeu Paulino
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado