Effects of Aerobic Exercise Training on Cardiac Renin-Angiotensin System in an Obese Zucker Rat Strain

Autor(es)

Mendes Barretti, Diego Lopes ^[1] ; Magalhaes, Flavio de Castro ^[1] ; Fernandes, Tiago ^[1] ; do Carmo, Everton Crivoi ^[1] ; Rosa, Kaleizu Teodoro ^[2] ; Irigoyen, Maria Claudia ^[2] ; Negrao, Carlos Eduardo ^{[2, 1]} ; Oliveira, Edilamar Menezes ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Lab Biochem & Mol Biol Exercise, Sch Phys Educ & Sport, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Sch Med, Heart Inst InCor, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: PLoS One; v. 7, n. 10 OCT 12 2012.
• Citações Web of Science: 30

Resumo

Objective: Obesity and renin angiotensin system (RAS) hyperactivity are profoundly involved in cardiovascular diseases, however aerobic exercise training (EXT) can prevent obesity and cardiac RAS activation. The study hypothesis was to investigate whether obesity and its association with EXT alter the systemic and cardiac RAS components in an obese Zucker rat strain. Methods: The rats were divided into the following groups: Lean Zucker rats (LZR); lean Zucker rats plus EXT (LZR+EXT); obese Zucker rats (OZR) and obese Zucker rats plus EXT (OZR+EXT). EXT consisted of 10 weeks of 60-min swimming sessions, 5 days/week. At the end of the training protocol heart rate (HR), systolic blood pressure (SBP), cardiac hypertrophy (CH) and function, local and systemic components of RAS were evaluated. Also, systemic glucose, triglycerides, total cholesterol and its LDL and HDL fractions were measured. Results: The resting HR decreased (, 12%) for both LZR+EXT and OZR+EXT. However, only the LZR+EXT reached significance (p, 0.05), while a tendency was found for OZR versus OZR+EXT (p = 0.07). In addition, exercise reduced (57%) triglycerides and (61%) LDL in the OZR+EXT. The systemic angiotensin I-converting enzyme (ACE) activity did not differ regardless of obesity and EXT, however, the OZR and OZR+EXT showed (66%) and (42%), respectively, less angiotensin II (Ang II) plasma concentration when compared with LZR. Furthermore, the results showed that EXT in the OZR prevented increase in CH, cardiac ACE activity, Ang II and AT2 receptor caused by obesity. In addition, exercise augmented cardiac ACE2 in both training groups. Conclusion: Despite the unchanged ACE and lower systemic Ang II levels in obesity, the cardiac RAS was increased in OZR and EXT in obese Zucker rats reduced some of the cardiac RAS components and prevented obesity-related CH. These results show that EXT prevented the heart RAS hyperactivity and cardiac maladaptive morphological alterations in obese Zucker rats. (AU)

• Processo FAPESP: 07/52458-0 - Efeitos do treinamento fisico aerobio sobre o sistema renina angiotensina cardiaco e sistemico de ratos obesos.
• Beneficiário: Diego Lopes Mendes Barretti
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 07/56771-4 - Efeitos do treinamento fisico aerobico na modulacao das celulas progenitoras endoteliais derivadas da medula ossea em ratos espontaneamente hipertensos (shr)
• Beneficiário: Tiago Fernandes
• Modalidade de apoio: Bolsas no Brasil - Mestrado