Is podoplanin expression associated with the proliferative activity of ameloblastomas?

Autor(es)

Tjioe, K. C. ^[1] ; Oliveira, D. T. ; Soares, C. T. ^[2] ; Lauris, J. R. P. ^[3] ; Damante, J. H.

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Bauru Sch Dent, Area Pathol, Dept Stomatol, BR-17012901 Sao Paulo - Brazil

^[2] Lauro de Souza Lima Inst, Dept Pathol, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Bauru Sch Dent, Dept Community Dent, BR-17012901 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ORAL DISEASES; v. 18, n. 7, p. 673-679, OCT 2012.
• Citações Web of Science: 10

Resumo

Oral Diseases (2012) 18, 673679 Objectives: The aim of this study was to investigate the relationship between podoplanin expression and proliferative activity of ameloblastomas and remnants of the odontogenic epithelium from dental follicles (DF) of unerupted teeth. Subjects and methods: Thirty-three paraffin-embedded ameloblastomas and thirty-two DF obtained of unerupted teeth were analyzed by immunohistochemistry using anti-human podoplanin and anti-Ki-67 antibodies. Podoplanin expression in odontogenic epithelial cells was evaluated using a scoring method, and the Ki-67 labeling index was determined by the percentage of positive odontogenic cells. Results: All ameloblastomas displayed podoplanin expression in ameloblast-like cells of the epithelial islands. Membranous expression of podoplanin in ameloblastomas was stronger than in the remnants of odontogenic epithelium (P = 0.001). Statistically significant difference was observed between the cytoplasmic and membranous expression of podoplanin in the remnants of odontogenic epithelium (P = 0.001). The index of epithelial odontogenic proliferative activity, verified by Ki-67 expression, was higher in ameloblastomas vs remnants of odontogenic epithelium (P < 0.001). No statistically significant correlation was identified between podoplanin and the cellular odontogenic proliferative activity in ameloblastomas and DF (P > 0.05). Conclusions: These results provide evidence that there is no connection between podoplanin immunostaining and odontogenic cellular proliferative activity and suggest a role for membranous podoplanin expression in the local invasion of ameloblastomas. (AU)

• Processo FAPESP: 09/12811-8 - Expressão da podoplanina em ameloblastomas e folículos pericoronários de dentes não-irrompidos: Estudo comparativo com a expressão do Ki-67
• Beneficiário: José Humberto Damante
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 09/12813-0 - Expressão da podoplanina em ameloblastomas e folículos pericoronários de dentes não-irrompidos: Estudo comparativo com a expressão do Ki-67
• Beneficiário: Kellen Cristine Tjioe
• Modalidade de apoio: Bolsas no Brasil - Mestrado