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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Is podoplanin expression associated with the proliferative activity of ameloblastomas?

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Author(s):
Tjioe, K. C. [1] ; Oliveira, D. T. ; Soares, C. T. [2] ; Lauris, J. R. P. [3] ; Damante, J. H.
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Bauru Sch Dent, Area Pathol, Dept Stomatol, BR-17012901 Sao Paulo - Brazil
[2] Lauro de Souza Lima Inst, Dept Pathol, Sao Paulo - Brazil
[3] Univ Sao Paulo, Bauru Sch Dent, Dept Community Dent, BR-17012901 Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: ORAL DISEASES; v. 18, n. 7, p. 673-679, OCT 2012.
Web of Science Citations: 10
Abstract

Oral Diseases (2012) 18, 673679 Objectives: The aim of this study was to investigate the relationship between podoplanin expression and proliferative activity of ameloblastomas and remnants of the odontogenic epithelium from dental follicles (DF) of unerupted teeth. Subjects and methods: Thirty-three paraffin-embedded ameloblastomas and thirty-two DF obtained of unerupted teeth were analyzed by immunohistochemistry using anti-human podoplanin and anti-Ki-67 antibodies. Podoplanin expression in odontogenic epithelial cells was evaluated using a scoring method, and the Ki-67 labeling index was determined by the percentage of positive odontogenic cells. Results: All ameloblastomas displayed podoplanin expression in ameloblast-like cells of the epithelial islands. Membranous expression of podoplanin in ameloblastomas was stronger than in the remnants of odontogenic epithelium (P = 0.001). Statistically significant difference was observed between the cytoplasmic and membranous expression of podoplanin in the remnants of odontogenic epithelium (P = 0.001). The index of epithelial odontogenic proliferative activity, verified by Ki-67 expression, was higher in ameloblastomas vs remnants of odontogenic epithelium (P < 0.001). No statistically significant correlation was identified between podoplanin and the cellular odontogenic proliferative activity in ameloblastomas and DF (P > 0.05). Conclusions: These results provide evidence that there is no connection between podoplanin immunostaining and odontogenic cellular proliferative activity and suggest a role for membranous podoplanin expression in the local invasion of ameloblastomas. (AU)

FAPESP's process: 09/12811-8 - Expression of podoplanin in ameloblastomas and dental follicles of unerupted teeth: Comparative study with the Ki-67 expression
Grantee:José Humberto Damante
Support Opportunities: Regular Research Grants
FAPESP's process: 09/12813-0 - Expression of podoplanin in ameloblastomas and dental follicles of unerupted teeth: Comparative study with the Ki-67 expression
Grantee:Kellen Cristine Tjioe
Support Opportunities: Scholarships in Brazil - Master