Fractal dimension and Shannon's entropy analyses of the architectural complexity caused by the inflammatory reactions induced by highly crystalline poly(vinyl alcohol) microspheres implanted in subcutaneous tissues of the Wistar rats

Autor(es)

Silva, Danilo A. ^[1] ; Basso, Glaucia G. ^{[2, 1]} ; Semenzim, Vinicius L. ^{[2, 1]} ; Godoy, Moacir F. ^[3] ; Taboga, Sebastiao R. ^[4] ; Andrade, Alexandre L. ^[5] ; Luvizotto, Maria C. R. ^[4] ; Braile, Domingo M. ^[2] ; Nery, Jose G. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Paulista UNESP, Inst Biociencias Letras & Ciencias Exatas, Dept Fis, BR-15054000 Sao Paulo - Brazil

^[2] Comercio & Representacoes Ltd, Braile Biomed Ind, BR-15091450 Sao Paulo - Brazil

^[3] Fac Med Sao Jose Rio Preto FAMERP, NUTECC, Dept Cardiol & Cirurgia Cardiovasc, BR-15090000 Sao Paulo - Brazil

^[4] Univ Estadual Paulista UNESP, Inst Biociencias Letras & Ciencias Exatas, Dept Biol, BR-15054000 Sao Paulo - Brazil

^[5] Univ Estadual Paulista UNESP, Fac Med Vet, Dept Clin Cirurgia & Reprod Anim, BR-16050680 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Biomedical Materials Research Part A; v. 101, n. 2, p. 326-339, FEB 2013.
• Citações Web of Science: 7

Resumo

The results of the histopathological analyses after the implantation of highly crystalline PVA microspheres in subcutaneous tissues of Wistar rats are here in reported. Three different groups of PVA microparticles were systematically studied: highly crystalline, amorphous, and commercial ones. In addition to these experiments, complementary analyses of architectural complexity were performed using fractal dimension (FD), and Shannon's entropy (SE) concepts. The highly crystalline microspheres induced inflammatory reactions similar to the ones observed for the commercial ones, while the inflammatory reactions caused by the amorphous ones were less intense. Statistical analyses of the subcutaneous tissues of Wistar rats implanted with the highly crystalline microspheres resulted in FD and SE values significantly higher than the statistical parameters observed for the amorphous ones. The FD and SE parameters obtained for the subcutaneous tissues of Wistar rats implanted with crystalline and commercial microparticles were statistically similar. Briefly, the results indicated that the new highly crystalline microspheres had biocompatible behavior comparable to the commercial ones. In addition, statistical tools such as FD and SE analyses when combined with histopathological analyses can be useful tools to investigate the architectural complexity tissues caused by complex inflammatory reactions. (c) 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2013. (AU)

• Processo FAPESP: 05/54703-6 - Síntese de catalisadores sólidos enantioseletivos: o desafio intelectual, tecnológico e sintético de zeólitas quirais
• Beneficiário: Jose Geraldo Nery
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores