Symptoms of anxiety and mood disturbance alter cardiac and peripheral autonomic control in patients with metabolic syndrome

Autor(es)

Toschi-Dias, Edgar ^[1] ; Trombetta, Ivani C. ^[1] ; Dias da Silva, Valdo Jose ^[2] ; Maki-Nunes, Cristiane ^[1] ; Alves, Maria Janieire N. N. ^[1] ; Angelo, Luciana F. ^[1] ; Cepeda, Felipe X. ^[1] ; Martinez, Daniel G. ^[1] ; Negrao, Carlos Eduardo ^{[3, 1]} ; Rondon, Maria Urbana P. B. ^{[3, 1]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Med, Heart Inst InCor, BR-05508030 Sao Paulo - Brazil

^[2] Univ Fed Triangulo Mineiro, Sch Med, Uberaba, MG - Brazil

^[3] Univ Sao Paulo, Sch Phys Educ & Sport, BR-05508030 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY; v. 113, n. 3, p. 671-679, MAR 2013.
• Citações Web of Science: 6

Resumo

Previous investigations show that metabolic syndrome (MetSyn) causes sympathetic hyperactivation. Symptoms of anxiety and mood disturbance (AMd) provoke sympatho-vagal imbalance. We hypothesized that AMd would alter even further the autonomic function in patients with MetSyn. Twenty-six never-treated patients with MetSyn (ATP-III) were allocated to two groups, according to the levels of anxiety and mood disturbance: (1) with AMd (MetSyn + AMd, n = 15), and (2) without AMd (MetSyn, n = 11). Ten healthy control subjects were also studied (C, n = 10). AMd was determined using quantitative questionnaires. Muscle sympathetic nerve activity (MSNA, microneurography), blood pressure (oscillometric beat-to-beat basis), and heart rate (ECG) were measured during a baseline 10-min period. Spectral analysis of RR interval and systolic arterial pressure were analyzed, and the power of low (LF) and high (HF) frequency bands were determined. Sympatho-vagal balance was obtained by LF/HF ratio. Spontaneous baroreflex sensitivity (BRS) was evaluated by calculation of alpha-index. MSNA was greater in patients with MetSyn + AMd compared with MetSyn and C. Patients with MetSyn + AMd showed higher LF and lower HF power compared with MetSyn and C. In addition, LF/HF balance was higher in MetSyn + AMd than in MetSyn and C groups. BRS was decreased in MetSyn + AMd compared with MetSyn and C groups. Anxiety and mood disturbance alter autonomic function in patients with MetSyn. This autonomic dysfunction may contribute to the increased cardiovascular risk observed in patients with mood alterations. (AU)

• Processo FAPESP: 08/03714-6 - Scan corporal 3D para diagnóstico de obesidade e avaliação do risco cardiovascular
• Beneficiário: Ivani Credidio Trombetta
• Modalidade de apoio: Bolsas no Exterior - Novas Fronteiras
• Processo FAPESP: 10/50048-1 - Bases celulares e funcionais do exercício físico na doença cardiovascular
• Beneficiário: Carlos Eduardo Negrão
• Modalidade de apoio: Auxílio à Pesquisa - Temático