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(Referência obtida automaticamente do SciELO, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

A novel bioactive glass-ceramic for treating dentin hypersensitivity

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Autor(es):
Camila Tirapelli ; Heitor Panzeri ; Rodrigo Gongalves Soares ; Oscar Peitl ; Edgar Dutra Zanotto
Número total de Autores: 5
Tipo de documento: Artigo Científico
Fonte: Brazilian Oral Research; v. 24, n. 4, p. 381-387, Dez. 2010.
Resumo

Dentin hypersensitivity (DH) is a painful response to stimulus applied to the open dentinal tubules of a vital tooth. It's a common oral condition, however, without an ideal treatment available yet. This work evaluated in vitro the effect of micron-sized particles from a novel bioactive glass-ceramic (Biosilicate) in occluding open dentinal tubules. A dentin disc model was employed to observe comparatively, using scanning electron microscopy (SEM), dentinal tubule occlusion by different products and deposition of hydroxyl carbonate apatite (HCA) on dentin surface by Biosilicate, after a single application: G1 - Dentifrice with potassium nitrate and fluoride; G2 - Two-step calcium phosphate precipitation treatment; G3 - Water-free gel containing Biosilicate particles (1%); G4 - Biosilicate particles mixed with distilled water in a 1:10 ratio; all of them after 1, 12 and 24 hours of immersion in artificial saliva. Fourier transform infrared spectroscopy (FTIR) was performed to detect HCA formation on dentin discs filled with Biosilicate after 2 minutes, 30 minutes and 12 hours of immersion in artificial saliva. SEM showed a layer of HCA formed on dentin surface after 24 hours by G4. G1, G2 and G3 promoted not total occlusion of open dentinal tubules after 24 hours. FTIR showed HCA precipitation on the dentin surface induced by Biosilicate after 30 minutes. The micron-sized particles from the bioactive glass-ceramic thus were able to induce HCA deposition in open dentinal tubules in vitro. This finding suggests that Biosilicate may provide a new option for treating DH. (AU)

Processo FAPESP: 07/08179-9 - Processos cinéticos em vidros e vitrocerâmicas
Beneficiário:Edgar Dutra Zanotto
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 04/05133-0 - Avaliação da eficácia de um biomaterial e conhecidos agentes dessensibilizantes no tratamento da hipersensibilidade dentinária: estudo in vitro e in vivo
Beneficiário:Heitor Panzeri
Linha de fomento: Auxílio à Pesquisa - Regular