Oxidative stress and its effects during dehydration

Autor(es)

França, M. B. ; Panek, A. D. ; Eleutherio, E. C. A.

• Tipo de documento: Artigo Científico
• Fonte: COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY; v. 146, n. 4, p. 621-631, Apr. 2007.
• Área do conhecimento: Ciências Biológicas - Bioquímica
• Assunto(s): Fungos Saccharomyces cerevisiae Desidratação Glutationa Peroxidação de lipídeos

Resumo

Water is usually thought to be required for the living state, but several organisms are capable of surviving complete dehydration (anhydrobiotes). Elucidation of the mechanisms of tolerance against dehydration may lead to development of new methods for preserving biological materials that do not normally support drying, which is of enormous practical importance in industry, in clinical medicine as well as in agriculture. One of the molecular mechanisms of damage leading to death in desiccation-sensitive cells upon drying is free-radical attack to phospholipids, DNA and proteins. This review aims to summarize the strategies used by anhydrobiotes to cope with the danger of oxygen toxicity and to present our recent results about the importance of some antioxidant defense systems in the dehydration tolerance of Saccharomyces cerevisiae, a usual model in the study of stress response. (AU)

• Processo FAPESP: 04/10067-6 - Estresse, transporte e metabolismo de alfa-glicosídios em Saccharomyces cerevisiae
• Beneficiário: Pedro Soares de Araujo
• Modalidade de apoio: Auxílio à Pesquisa - Temático