| Texto completo | |
| Autor(es): |
Leite, Mariana F.
[1]
;
Alves Aznar, Lauren Cardoso
[1]
;
Ferreira, Maria Cristina D.
[2]
;
Guare, Renata O.
[1]
;
Santos, Maria Teresa B.
[1]
Número total de Autores: 5
|
| Afiliação do(s) autor(es): | [1] Univ Cruzeiro Sul, BR-08060070 Sao Paulo - Brazil
[2] Univ Estadual Paulista, Brooklin Sao Paulo - Brazil
Número total de Afiliações: 2
|
| Tipo de documento: | Artigo Científico |
| Fonte: | JOURNAL OF ORAL PATHOLOGY & MEDICINE; v. 42, n. 6, p. 480-485, JUL 2013. |
| Citações Web of Science: | 4 |
| Resumo | |
BACKGROUND: Salivary immunoglobulin A (SIgA) together with innate defenses such as alpha-amylase, provides the `first line of defense' against pathogens present at mucosal surfaces. This study aimed to evaluate salivary alpha-amylase and immunoglobulin A (IgA) in whole saliva of spastic cerebral palsy (CP) individuals. METHODS: Whole saliva was collected from 22 CP and 24 sibling volunteers with no neurological damage control groups (CG) (aged 7-14 years). The salivary flow rate, total protein and SIgA concentrations, and alpha-amylase activity were determined. RESULTS: The CP group presented higher salivary flow rate (35%) and lower total protein concentration (18%) compared with the CG (P <= 0.05). CPG had higher absolute (68%, mu g SIgA/ml) and relative (55%, mu g SIgA/mg prot and 108%, mu g SIgA/min) concentrations of IgA compared with the CG (P <= 0.05). CPG had lower relative alpha-amylase activity (15% mg malt/mg prot and 33%, mg malt/min) compared with the CG (P <= 0.05). CONCLUSION: This study concluded that CP individuals presented alterations in the profile of salivary proteins involved in the defense system of the oral cavity. (AU) | |
| Processo FAPESP: | 08/00960-6 - Resposta autonômica em indivíduos com paralisia cerebral |
| Beneficiário: | Maria Teresa Botti Rodrigues dos Santos |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |