Increased salivary immunoglobulin A and reduced alpha-amylase activity in whole saliva from spastic cerebral palsy individuals

Author(s)

Leite, Mariana F. ^[1] ; Alves Aznar, Lauren Cardoso ^[1] ; Ferreira, Maria Cristina D. ^[2] ; Guare, Renata O. ^[1] ; Santos, Maria Teresa B. ^[1]

Affiliation

^[1] Univ Cruzeiro Sul, BR-08060070 Sao Paulo - Brazil

^[2] Univ Estadual Paulista, Brooklin Sao Paulo - Brazil

• Document type: Journal article
• Source: JOURNAL OF ORAL PATHOLOGY & MEDICINE; v. 42, n. 6, p. 480-485, JUL 2013.
• Web of Science Citations: 4

Abstract

BACKGROUND: Salivary immunoglobulin A (SIgA) together with innate defenses such as alpha-amylase, provides the `first line of defense' against pathogens present at mucosal surfaces. This study aimed to evaluate salivary alpha-amylase and immunoglobulin A (IgA) in whole saliva of spastic cerebral palsy (CP) individuals. METHODS: Whole saliva was collected from 22 CP and 24 sibling volunteers with no neurological damage control groups (CG) (aged 7-14 years). The salivary flow rate, total protein and SIgA concentrations, and alpha-amylase activity were determined. RESULTS: The CP group presented higher salivary flow rate (35%) and lower total protein concentration (18%) compared with the CG (P <= 0.05). CPG had higher absolute (68%, mu g SIgA/ml) and relative (55%, mu g SIgA/mg prot and 108%, mu g SIgA/min) concentrations of IgA compared with the CG (P <= 0.05). CPG had lower relative alpha-amylase activity (15% mg malt/mg prot and 33%, mg malt/min) compared with the CG (P <= 0.05). CONCLUSION: This study concluded that CP individuals presented alterations in the profile of salivary proteins involved in the defense system of the oral cavity. (AU)

• FAPESP's process: 08/00960-6 - Autonomic response in individuals with cerebral palsy
• Grantee: Maria Teresa Botti Rodrigues dos Santos
• Support Opportunities: Regular Research Grants