Time-Course of Neuroendocrine Changes and Its Correlation with Hypertension Induced by Ethanol Consumption

Autor(es)

da Silva, Andreia Lopes ^[1] ; Ruginsk, Silvia G. ^[1] ; Uchoa, Ernane Torres ^[1] ; Crestani, Carlos C. ^[2] ; Scopinho, America A. ^[3] ; Correa, Fernando Morgan A. ^[3] ; De Martinis, Bruno Spinosa ^[4] ; Kagohara Elias, Lucila Leico ^[1] ; Resstel, Leonardo B. ^[3] ; Antunes-Rodrigues, Jose ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Physiol, Sao Paulo - Brazil

^[2] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Nat Act Principles & Toxicol, Araraquara - Brazil

^[3] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Pharmacol, Sao Paulo - Brazil

^[4] Univ Sao Paulo, Dept Chem, Sch Philosophy Sci & Literature Ribeirao Preto, Ribeirao Preto - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ALCOHOL AND ALCOHOLISM; v. 48, n. 4, p. 495-504, JUL-AUG 2013.
• Citações Web of Science: 14

Resumo

Ethanol (ETOH) consumption has been associated with endocrine and autonomic changes, including the development of hypertension. However, the sequence of pathophysiological events underlying the emergence of this effect is poorly understood. Aims: This study aimed to establish a time-course correlation between neuroendocrine and cardiovascular changes contributing to the development of hypertension following ETOH consumption. Methods: Male adult Wistar rats were subjected to the intake of increasing ETOH concentrations in their drinking water (first week: 5%, second week: 10%, third and fourth weeks: 20% v/v). Results: ETOH consumption decreased plasma and urinary volumes, as well as body weight and fluid intake. Furthermore, plasma osmolality, plasma sodium and urinary osmolality were elevated in the ETOH-treated rats. ETOH intake also induced a progressive increase in the mean arterial pressure (MAP), without affecting heart rate. Initially, this increase in MAP was correlated with increased plasma concentrations of adrenaline and noradrenaline. After the second week of ETOH treatment, plasma catecholamines returned to basal levels, and incremental increases were observed in plasma concentrations of vasopressin (AVP) and angiotensin II (ANG II). Conversely, plasma oxytocin, atrial natriuretic peptide, prolactin and the hypothalamus-pituitary-adrenal axis components were not significantly altered by ETOH. Conclusions: Taken together, these results suggest that increased sympathetic activity may contribute to the early increase in MAP observed in ETOH-treated rats. However, the maintenance of this effect may be predominantly regulated by the long-term increase in the secretion of other circulating factors, such as AVP and ANG II, the secretion of both hormones being stimulated by the ETOH-induced dehydration. (AU)

• Processo FAPESP: 09/51676-9 - Caracterizacao dos efeitos humorais e cardiovasculares decorrentes do consumo cronico de etanol em ratos
• Beneficiário: Andréia Lopes Durand
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 08/50611-8 - Regulação neuroendócrina do equilíbrio hidrossalino e da ingestão alimentar: aspectos fisiológicos, fisiopatológicos e moleculares
• Beneficiário: José Antunes Rodrigues
• Modalidade de apoio: Auxílio à Pesquisa - Temático