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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Time-Course of Neuroendocrine Changes and Its Correlation with Hypertension Induced by Ethanol Consumption

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Author(s):
da Silva, Andreia Lopes [1] ; Ruginsk, Silvia G. [1] ; Uchoa, Ernane Torres [1] ; Crestani, Carlos C. [2] ; Scopinho, America A. [3] ; Correa, Fernando Morgan A. [3] ; De Martinis, Bruno Spinosa [4] ; Kagohara Elias, Lucila Leico [1] ; Resstel, Leonardo B. [3] ; Antunes-Rodrigues, Jose [1]
Total Authors: 10
Affiliation:
[1] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Physiol, Sao Paulo - Brazil
[2] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Nat Act Principles & Toxicol, Araraquara - Brazil
[3] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Pharmacol, Sao Paulo - Brazil
[4] Univ Sao Paulo, Dept Chem, Sch Philosophy Sci & Literature Ribeirao Preto, Ribeirao Preto - Brazil
Total Affiliations: 4
Document type: Journal article
Source: ALCOHOL AND ALCOHOLISM; v. 48, n. 4, p. 495-504, JUL-AUG 2013.
Web of Science Citations: 14
Abstract

Ethanol (ETOH) consumption has been associated with endocrine and autonomic changes, including the development of hypertension. However, the sequence of pathophysiological events underlying the emergence of this effect is poorly understood. Aims: This study aimed to establish a time-course correlation between neuroendocrine and cardiovascular changes contributing to the development of hypertension following ETOH consumption. Methods: Male adult Wistar rats were subjected to the intake of increasing ETOH concentrations in their drinking water (first week: 5%, second week: 10%, third and fourth weeks: 20% v/v). Results: ETOH consumption decreased plasma and urinary volumes, as well as body weight and fluid intake. Furthermore, plasma osmolality, plasma sodium and urinary osmolality were elevated in the ETOH-treated rats. ETOH intake also induced a progressive increase in the mean arterial pressure (MAP), without affecting heart rate. Initially, this increase in MAP was correlated with increased plasma concentrations of adrenaline and noradrenaline. After the second week of ETOH treatment, plasma catecholamines returned to basal levels, and incremental increases were observed in plasma concentrations of vasopressin (AVP) and angiotensin II (ANG II). Conversely, plasma oxytocin, atrial natriuretic peptide, prolactin and the hypothalamus-pituitary-adrenal axis components were not significantly altered by ETOH. Conclusions: Taken together, these results suggest that increased sympathetic activity may contribute to the early increase in MAP observed in ETOH-treated rats. However, the maintenance of this effect may be predominantly regulated by the long-term increase in the secretion of other circulating factors, such as AVP and ANG II, the secretion of both hormones being stimulated by the ETOH-induced dehydration. (AU)