Carcinoma ex-pleomorphic adenoma of upper lip showing copy number loss of tumor suppressor genes

Autor(es)

Mariano, Fernanda Viviane ^[1] ; Rincon, Daniel ^[2] ; Gondak, Rogerio Oliveira ^[1] ; Jorge, Rogerio ^[3] ; Lopes, Marcio Ajudarte ^[1] ; Altemani, Albina ^[4] ; de Almeida, Oslei Paes ^[1] ; Kowalski, Luiz Paulo ^[3]

Afiliação do(s) autor(es)

^[1] Univ Campinas UNICAMP, Piracicaba Dent Sch, Dept Oral Diag, Piracicaba, SP - Brazil

^[2] Univ Sao Paulo, Inst Biosci, Dept Genet & Evolutionary Biol, Sao Paulo - Brazil

^[3] Assoc Dent Surg Campinas ACDC, Oral Diag Serv, Campinas, SP - Brazil

^[4] Univ Campinas UNICAMP, Sch Med Sci, Dept Pathol Anat, Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY; v. 116, n. 1, p. 69-74, JUL 2013.
• Citações Web of Science: 2

Resumo

Background. Carcinoma ex-pleomorphic adenoma (CXPA) is a malignant salivary gland tumor that arises rarely in the minor salivary glands. Although the etiology of CXPA remains unclear, the role of some tumor suppressor genes and oncogenes in CXPA is documented; however, other genes still need to be studied. Study design and objective. An uncommon case of CXPA involving the upper lip is presented, which was analyzed by a panel of tumor suppressor genes by multiplex ligation-dependent probe amplification. Results. The genes investigated in this study, a loss of copy number was detected for CASP8, CD44, CDH1, DAPK1, ESR1, RASSF1, and TP73. Immunohistochemical reactions for the validation of some of these results showed negativity for CD44, RASSF1, and p73. Conclusion. A loss of copy number of the genes CD44, RASSF1, and TP73 may contribute to the carcinogenesis of CXPAs. (AU)

• Processo FAPESP: 11/23204-5 - Estudo do perfil genômico do carcinoma ex-adenoma pleomorfo por hibridização genômica comparativa em microarranjo (CGH array)
• Beneficiário: Albina Messias de Almeida Milani Altemani
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 11/23366-5 - Estudo do perfil genômico do carcinoma ex-adenoma pleomorfo por hibridização genômica comparativa em microarranjo (CGH array)
• Beneficiário: Fernanda Viviane Mariano Brum Corrêa
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado