Carcinoma ex-pleomorphic adenoma of upper lip showing copy number loss of tumor suppressor genes

Author(s)

Mariano, Fernanda Viviane ^[1] ; Rincon, Daniel ^[2] ; Gondak, Rogerio Oliveira ^[1] ; Jorge, Rogerio ^[3] ; Lopes, Marcio Ajudarte ^[1] ; Altemani, Albina ^[4] ; de Almeida, Oslei Paes ^[1] ; Kowalski, Luiz Paulo ^[3]

Affiliation

^[1] Univ Campinas UNICAMP, Piracicaba Dent Sch, Dept Oral Diag, Piracicaba, SP - Brazil

^[2] Univ Sao Paulo, Inst Biosci, Dept Genet & Evolutionary Biol, Sao Paulo - Brazil

^[3] Assoc Dent Surg Campinas ACDC, Oral Diag Serv, Campinas, SP - Brazil

^[4] Univ Campinas UNICAMP, Sch Med Sci, Dept Pathol Anat, Campinas, SP - Brazil

• Document type: Journal article
• Source: ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY; v. 116, n. 1, p. 69-74, JUL 2013.
• Web of Science Citations: 2

Abstract

Background. Carcinoma ex-pleomorphic adenoma (CXPA) is a malignant salivary gland tumor that arises rarely in the minor salivary glands. Although the etiology of CXPA remains unclear, the role of some tumor suppressor genes and oncogenes in CXPA is documented; however, other genes still need to be studied. Study design and objective. An uncommon case of CXPA involving the upper lip is presented, which was analyzed by a panel of tumor suppressor genes by multiplex ligation-dependent probe amplification. Results. The genes investigated in this study, a loss of copy number was detected for CASP8, CD44, CDH1, DAPK1, ESR1, RASSF1, and TP73. Immunohistochemical reactions for the validation of some of these results showed negativity for CD44, RASSF1, and p73. Conclusion. A loss of copy number of the genes CD44, RASSF1, and TP73 may contribute to the carcinogenesis of CXPAs. (AU)

• FAPESP's process: 11/23204-5 - Genomic profile study of carcinoma ex-pleomorphic adenoma by array-comparative genomic hybridization
• Grantee: Albina Messias de Almeida Milani Altemani
• Support type: Regular Research Grants
• FAPESP's process: 11/23366-5 - Genomic profile study of carcinoma ex-pleomorphic adenoma by array-comparative genomic hybridization
• Grantee: Fernanda Viviane Mariano Brum Corrêa
• Support type: Scholarships in Brazil - Post-Doctorate