Leucine supplementation increases serum insulin-like growth factor 1 concentration and liver protein/RNA ratio in rats after a period of nutritional recovery

Autor(es)

Pedrosa, Rogerio G. ^[1] ; Donato, Jr., Jose ^[2] ; Pires, Ivanir S. ^[3] ; Tirapegui, Julio ^[3]

Afiliação do(s) autor(es)

^[1] Univ Fed Espirito Santo, Dept Educ Integrada Saude, Ctr Ciencias Saude, BR-29043900 Vitoria, ES - Brazil

^[2] Univ Sao Paulo, Dept Physiol & Biophys, Inst Biomed Sci, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Dept Food Sci & Expt Nutr, Fac Pharmaceut Sci, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: APPLIED PHYSIOLOGY NUTRITION AND METABOLISM; v. 38, n. 6, p. 694-697, JUN 2013.
• Citações Web of Science: 6

Resumo

This study evaluated the effect of leucine on the protein status of rats submitted to 50% food restriction for 1 week, followed by 2 weeks of nutritional recovery. A significant increase of serum insulin-like growth factor 1 and protein/RNA ratio in the liver was observed in leucine-supplemented rats. There was no change in carcass, liver, or gastrocnemius protein content when compared with control animals. The supplementation tested did not favor protein status, although it improved some indicators of an anabolic state. (AU)

• Processo FAPESP: 10/18086-0 - Bases moleculares da resistência à leptina
• Beneficiário: Jose Donato Junior
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores