Resistance exercise: A non-pharmacological strategy to minimize or reverse sleep deprivation-induced muscle atrophy

Autor(es)

Monico-Neto, M. ^{[1, 2]} ; Antunes, H. K. M. ^{[2, 3]} ; Dattilo, M. ^{[1, 2]} ; Medeiros, A. ^[3] ; Souza, H. S. ^{[1, 2]} ; Lee, K. S. ^[4] ; de Melo, C. M. ^{[1, 2]} ; Tufik, S. ^{[1, 2]} ; de Mello, M. T. ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Dept Psicobiol, Sao Paulo - Brazil

^[2] CEPE, Sao Paulo - Brazil

^[3] Univ Fed Sao Paulo, Dept Biociencias, Santos - Brazil

^[4] Univ Fed Sao Paulo, Dept Bioquim, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Medical Hypotheses; v. 80, n. 6, p. 701-705, JUN 2013.
• Citações Web of Science: 9

Resumo

Sleep is important for maintenance of skeletal muscle health. Sleep debt can induce muscle atrophy by increasing glucocorticoids and decreasing testosterone, growth hormone and insulin-like growth factor-I. These hormonal alterations result in a highly proteolytic environment characterized by decreased protein synthesis and increased degradation. Given that sleep deprivation is increasingly prevalent in modern society, strategies to minimize or reverse its adverse effects need to be investigated. Resistance exercise has been suggested as an intervention that would benefit the muscle health. The practice of this type of exercise can increase the concentration of testosterone, growth hormone and insulin-like growth factor I and stimulate the protein synthesis through a key signaling molecule, mammalian target of rapamycin. Thus, we hypothesized that resistance exercise is an important non-pharmacological strategy to counteract deleterious effects of sleep debt on skeletal muscle. (C) 2013 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 11/15962-7 - Efeitos do exercício físico resistido nas vias tróficas e atróficas da musculatura esquelética de ratos submetidos à privação de sono paradoxal
• Beneficiário: Marcos Mônico Neto
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 98/14303-3 - Center for Sleep Studies
• Beneficiário: Sergio Tufik
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs