Phenylpropanoid glucosides from leaves of Coussarea hydrangeifolia (Rubiaceae)

Autor(es)

Hamerski, Lidilhone ; Bomm, Mauro Dionei ; Silva, Dulce Helena Siqueira ; Young, Maria Cláudia Marx ; Furlan, Maysa ; Eberlin, Marcos Nogueira ; Castro-Gamboa, Ian ; Cavalheiro, Alberto José ; Bolzani, Vanderlan da Silva ^[9]

• Tipo de documento: Artigo Científico
• Fonte: Phytochemistry; v. 66, n. 16, p. 1927-1932, Aug. 2005.
• Área do conhecimento: Ciências Exatas e da Terra - Química
• Assunto(s): Rubiaceae Glicosídeos

Resumo

Phenylpropanoid glycosides, 1 '-O-benzyl-alpha-(L)-rhamnopyranosyl-(1 ''-> 6 ')-beta-(D)-glucopyranoside (1) and alpha-(L)-Xylopyranosyl(4 '', 2 ')-(3-O-beta-(D)-glucopyranosyl)-1 '-O-E-caffeoyl-beta-(D)-glucopyranoside (2), together with the known derivatives, 1,6-di-O-caffeoyl- beta-(D)-glucopyrano side (3), 1-O-(E)-caffeoyl-beta-(D)-glucopyranoside (4) and 1-O-(E)-feruloyl-beta-(D)-glucopyranoside (5), were isolated from leaves of Coussarea hydrangeifolia. Their structures were determined by IR, HRESIMS, and I D and 2D NMR experiments, and their antioxidant activities, evaluated by assaying the free radical scavenging capacity using the DPPH (1,1-diphenyl-2-picrylhydrazyl) radical as substrate. The antioxidant activities of 3 and 4 (IC50 values of 15.0 and 19.2 mu M, respectively) were comparable to that of the standard positive control caffeic acid, whilst 2 and 5 were only weakly active and 1 was inactive. (AU)

• Processo FAPESP: 98/05074-0 - Conservação e uso sustentável da biodiversidade vegetal do Cerrado e da Mata Atlântica: diversidade química e prospecção de medicamentos potenciais
• Beneficiário: Vanderlan da Silva Bolzani
• Modalidade de apoio: Auxílio à Pesquisa - Programa BIOTA - Temático