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(Referência obtida automaticamente do SciELO, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Antiproliferative activity of methanol extracts of four species of Croton on different human cell lines

Texto completo
Autor(es):
Savietto, Joice P. [1] ; Furlan, Claudia M. [1] ; Motta, Lucimar B. [1] ; Salatino, Maria Luiza F. [1] ; Carvalho, Joao E. [2] ; Ruiz, Ana Lucia T. G. [2] ; Salatino, Antonio [1] ; Santos, Deborah Yara A. C. [1]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Inst Biociencias, Dept Bot, BR-05508090 Sao Paulo - Brazil
[2] Univ Estadual Campinas, CPQBA, Div Farmacol & Toxicol, BR-13081970 Campinas, SP - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY; v. 23, n. 4, p. 662-667, Ago. 2013.
Citações Web of Science: 5
Resumo

Several species of Croton have been described with biological activities, mainly due to diterpenes, alkaloids and/or other secondary metabolites. These activities account for the traditional use of Croton species to treat certain diseases in South America, Asia and Western Africa. The crude methanol extracts obtained from leaves and steam bark of Croton dichrous Müll. Arg., C. erythroxyloides Baill., C. myrianthus Müll. Arg. and C. splendidus Mart. ex Colla were tested for antiproliferative activity against ten human cancer cell lines. Chemical analyses of all extracts were carried out by GC/MS and HPLC/MS/MS. The leaf extract obtained from C. erythroxyloides showed potent activity against PC-3 (prostate) and OVCAR-3 (ovary) cell lines. Lupeol is suggested to be involved in such activity. Tiliroside, an acyl-glycosilated flavonoid ubiquitous in all tested extracts, seems to play an important role in the observed moderate activity of most extracts against the leukemia K562 cell lineage. (AU)

Processo FAPESP: 07/02518-6 - Química, potencial farmacológico e filogenia molecular de Croton (Euphorbiaceae), com ênfase em espécies nativas
Beneficiário:Antonio Salatino
Linha de fomento: Auxílio à Pesquisa - Regular