Antiproliferative activity of methanol extracts of four species of Croton on different human cell lines

Autor(es)

Jóice P. Savietto ^[1] ; Cláudia M. Furlan ^[2] ; Lucimar B. Motta ^[3] ; Maria Luiza F. Salatino ^[3] ; João E. Carvalho ^[5] ; Ana Lucia T. G. Ruiz ^[5] ; Antonio Salatino ^[3] ; Déborah Yara A. C. Santos ^[8]

Afiliação do(s) autor(es)

^[1] Universidade de São Paulo. Instituto de Biociências. Departamento de Botânica - Brasil

^[2] Universidade de São Paulo. Instituto de Biociências. Departamento de Botânica - Brasil

^[3] Univ Sao Paulo, Inst Biociencias, Dept Bot, BR-05508090 Sao Paulo - Brazil

^[4] Universidade Estadual de Campinas. CPQBA. Divisão de Farmacologia e Toxicologia - Brasil

^[5] Univ Estadual Campinas, CPQBA, Div Farmacol & Toxicol, BR-13081970 Campinas, SP - Brazil

^[6] Universidade de São Paulo. Instituto de Biociências. Departamento de Botânica - Brasil

• Tipo de documento: Artigo Científico
• Fonte: REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY; v. 23, n. 4, p. 662-667, 2013-08-20.

Resumo

Several species of Croton have been described with biological activities, mainly due to diterpenes, alkaloids and/or other secondary metabolites. These activities account for the traditional use of Croton species to treat certain diseases in South America, Asia and Western Africa. The crude methanol extracts obtained from leaves and steam bark of Croton dichrous Müll. Arg., C. erythroxyloides Baill., C. myrianthus Müll. Arg. and C. splendidus Mart. ex Colla were tested for antiproliferative activity against ten human cancer cell lines. Chemical analyses of all extracts were carried out by GC/MS and HPLC/MS/MS. The leaf extract obtained from C. erythroxyloides showed potent activity against PC-3 (prostate) and OVCAR-3 (ovary) cell lines. Lupeol is suggested to be involved in such activity. Tiliroside, an acyl-glycosilated flavonoid ubiquitous in all tested extracts, seems to play an important role in the observed moderate activity of most extracts against the leukemia K562 cell lineage. (AU)

• Processo FAPESP: 07/02518-6 - Química, potencial farmacológico e filogenia molecular de Croton (Euphorbiaceae), com ênfase em espécies nativas
• Beneficiário: Antonio Salatino
• Modalidade de apoio: Auxílio à Pesquisa - Regular