Effects of Cachaca, a typical Brazilian alcoholic beverage, on alveolar bone loss and density: A study in peripubertal rats

Autor(es)

Bastos, Marta Ferreira ^[1] ; Dore Gaag, Giovanna Lima ^[1] ; Romero, Jose Renato ^[2] ; Megale Gabrili, Joel Jose ^[1] ; Marques, Marcelo Rocha ^[3] ; Duarte, Poliana Mendes ^[1]

Afiliação do(s) autor(es)

^[1] Univ Guarulhos, Dent Res Div, Dept Periodont, Guarulhos, SP - Brazil

^[2] Univ Guarulhos, Dept Physiotherapy, Guarulhos, SP - Brazil

^[3] Univ Estadual Campinas, Sch Dent Piracicaba, Div Histol, Dept Morphol, Piracicaba, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ARCHIVES OF ORAL BIOLOGY; v. 59, n. 1, p. 82-91, JAN 2014.
• Citações Web of Science: 4

Resumo

Objective: The aim of the present study was to assess the impact of chronic consumption of Cachaca on alveolar bone loss (BL) induced by ligature and on alveolar bone density (BD) in peripubertal rats. Design: Male Wistar rats were assigned into one of the following groups: Control: non-ingestion of Cachaca (n = 15); Cachaca: ingestion of ascending concentrations of Cachaca during 100 days (n = 15). 70th day after the beginning of Cachaca ingestion, one first mandibular molar received a ligature while the contralateral tooth was left unligated. After 30 days, the rats were killed. BL, BD, the positive cells for tartrate-resistant acid phosphatase (TRAP), receptor activator of NF-kappa B ligand (RANKL) and osteoprotegerin (OPG) were analyzed in the furcation area of the ligated and unligated mandibular molars. Results: The Cachaca group presented greater BL (0.75 +/- 0.1 mm(2) for Cachaca and 0.66 +/- 0.1 mm(2) for control group, respectively) and number of RANKL and OPG+ cells and lower BD (60.3 +/- 4.2% for Cachaca and 76.8 +/- 3.8% for control group, respectively) and number of TRAP+ cells around ligated teeth (p < 0.05), when compared to the control group. The Cachaca group (0.42 +/- 0.02 mm(2)) also presented a higher BL around unligated teeth when compared to control group (0.31 +/- 0.05 mm(2)). Conclusions: Cachaca consumption per se and in the presence of ligature negatively affects alveolar bone by increasing the alveolar BL and reducing BD. (C) 2013 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 09/09446-6 - Impacto da ingestão crônica de cafeína associada ou não a osteoporose na perda óssea alveolar induzida por ligadura, na densidade e reparo ósseo em ratas
• Beneficiário: Marta Ferreira Bastos
• Modalidade de apoio: Auxílio à Pesquisa - Regular