Differential pulse voltammetric determination of albendazole in pharmaceutical tablets using a cathodically pretreated boron-doped diamond electrode

Autor(es)

Lourencao, Bruna C. ^[1] ; Baccarin, Marina ^[1] ; Medeiros, Roberta A. ^[1] ; Rocha-Filho, Romeu C. ^[1] ; Fatibello-Filho, Orlando ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Carlos, Dept Quim, BR-13560970 Sao Carlos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF ELECTROANALYTICAL CHEMISTRY; v. 707, p. 15-19, OCT 15 2013.
• Citações Web of Science: 28

Resumo

A sensitive, simple, and rapid electrochemical method was developed for the determination of albendazole (ABZ) in anthelminthic pharmaceutical formulations using differential pulse voltammetry (DPV) with a cathodically pretreated boron-doped diamond (BDD) electrode and 0.05 mol L-1 H2SO4 as supporting electrolyte. The electrochemical behavior of ABZ obtained with cyclic voltammetry (CV) showed two oxidation peaks at 0.95 and 1.30 V vs. Ag/AgC1 (3.0 mol L-1 KC1). The total number of electrons (four) transferred during the oxidation process was estimated from the scan rate dependence of this CV response. The proposed method resulted in an analytical curve ranging from 0.0797 to 8.36 umol L-1, with a detection limit (based on 3-sigma) of 0.0625 mu mol L-1. This novel DPV method was successfully applied to determine ABZ in three pharmaceutical formulations (tablets), with results similar to those obtained using a reference HPLC method. (C) 2013 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 09/17729-8 - Eletrodo de Diamante Dopado com Boro para a Determinação Voltamétrica/ Amperométrica de Anti-helminticos e Anti-hipertensivos
• Beneficiário: Bruna Cláudia Lourenção
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 11/00601-9 - Aplicação de eletrodos de diamante dopado com boro e de nitreto de carbono amorfo para a determinação simultânea de fármacos de diferentes grupos terapêuticos em formulações farmacêuticas e em urina
• Beneficiário: Roberta Antigo Medeiros
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado