Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Differential pulse voltammetric determination of albendazole in pharmaceutical tablets using a cathodically pretreated boron-doped diamond electrode

Full text
Author(s):
Lourencao, Bruna C. [1] ; Baccarin, Marina [1] ; Medeiros, Roberta A. [1] ; Rocha-Filho, Romeu C. [1] ; Fatibello-Filho, Orlando [1]
Total Authors: 5
Affiliation:
[1] Univ Fed Sao Carlos, Dept Quim, BR-13560970 Sao Carlos, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: JOURNAL OF ELECTROANALYTICAL CHEMISTRY; v. 707, p. 15-19, OCT 15 2013.
Web of Science Citations: 28
Abstract

A sensitive, simple, and rapid electrochemical method was developed for the determination of albendazole (ABZ) in anthelminthic pharmaceutical formulations using differential pulse voltammetry (DPV) with a cathodically pretreated boron-doped diamond (BDD) electrode and 0.05 mol L-1 H2SO4 as supporting electrolyte. The electrochemical behavior of ABZ obtained with cyclic voltammetry (CV) showed two oxidation peaks at 0.95 and 1.30 V vs. Ag/AgC1 (3.0 mol L-1 KC1). The total number of electrons (four) transferred during the oxidation process was estimated from the scan rate dependence of this CV response. The proposed method resulted in an analytical curve ranging from 0.0797 to 8.36 umol L-1, with a detection limit (based on 3-sigma) of 0.0625 mu mol L-1. This novel DPV method was successfully applied to determine ABZ in three pharmaceutical formulations (tablets), with results similar to those obtained using a reference HPLC method. (C) 2013 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 09/17729-8 - Boron-Doped Diamond Electrode for the Determination Voltametric/ Amperometric of Anti-Helmintic and antihypertensive Drugs
Grantee:Bruna Cláudia Lourenção
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 11/00601-9 - Application of boron-doped diamond and amorphous carbon nitride electrodes for the simultaneous determination of drugs of different therapeutic groups in pharmaceutical formulations and urine samples
Grantee:Roberta Antigo Medeiros
Support Opportunities: Scholarships in Brazil - Post-Doctoral