Podoplanin and VEGF-C Immunoexpression in Oral Squamous Cell Carcinomas: Prognostic Significance

Autor(es)

Almeida, Aroldo Dos Santos ^[1] ; Oliveira, Denise Tostes ^[1] ; Pereira, Michele Conceicao ^[2] ; Sita Faustino, Simone Eloiza ^[1] ; Nonogaki, Suely ^[3] ; Carvalho, Andre Lopes ^[4] ; Kowalski, Luiz Paulo ^[5]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Bauru Sch Dent, Dept Stomatol, Sect Pathol, Sao Paulo - Brazil

^[2] Univ Fed Sao Joao del Rei, Divinopolis, MG - Brazil

^[3] Adolfo Lutz Inst, Sao Paulo - Brazil

^[4] Barretos Canc Hosp, Dept Head & Neck Surg, Barretos, SP - Brazil

^[5] Canc Hosp AC Camargo, Dept Head & Neck Surg & Otorhinolaryngol, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ANTICANCER RESEARCH; v. 33, n. 9, p. 3969-3976, SEP 2013.
• Citações Web of Science: 10

Resumo

Background: This study evaluated the clinical significance of podoplanin and vascular endothelial growth factor-C (VEGF-C) expression in oral squamous cell carcinoma (OSCC). Patients and Methods: The immunohistochemical expression of podoplanin and VEGF-C were investigated in 42 well-differentiated OSCCs. The Chi-square test was used to analyze the association of biomarker expression with the clinical characteristics, treatment, and outcome, as well as with histopathological microscopic features and histopathological malignancy index. The relationship between podoplanin, VEGF-C and prognosis was also studied. Survival rates were calculated by the Kaplan Meier method. Results: Strong podoplanin expression was associated with male gender (p=0.037) and with early clinical stage (I-II) (p=0.027). Strong podoplanin expression was more frequently found in patients with perineural infiltration. Podoplanin and VEGF-C expression were not significant prognostic factors for patients with OSCC. Conclusion: These results suggest that the strong podoplanin and VEGF-C expression by malignant cells is associated with perineural invasion in patients with OSCC. (AU)

• Processo FAPESP: 05/04577-4 - Influência do VEGF-C e da densidade de vasos linfáticos nas metástases linfonodais e no prognóstico de pacientes com carcinoma espinocelular de boca
• Beneficiário: Denise Tostes Oliveira
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 07/04907-0 - VEGF-C e densidade de vasos linfáticos em carcinoma espinocelular de boca: associação com as metástases linfonodais ocultas e com o prognóstico dos pacientes
• Beneficiário: Simone Eloiza Sita Faustino
• Modalidade de apoio: Bolsas no Brasil - Doutorado