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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Comparison of oxidative stress in ASA physical status I patients scheduled for minimally invasive surgery under balanced or intravenous anesthesia

Autor(es):
Braz, M. G. [1] ; Braz, L. G. [1] ; Braz, J. R. [1] ; Pierine, D. T. [2] ; Correa, C. R. [2] ; Ferreira, A. L. [3] ; Carvalho, L. R. [4] ; Yeum, K. J. [5, 6] ; Salvadori, D. M. [2]
Número total de Autores: 9
Afiliação do(s) autor(es):
[1] Univ Estadual Paulista, UNESP, Fac Med Botucatu, Dept Anesthesiol, Botucatu, SP - Brazil
[2] Univ Estadual Paulista, UNESP, Fac Med Botucatu, Dept Pathol, Botucatu, SP - Brazil
[3] Univ Estadual Paulista, UNESP, Fac Med Botucatu, Dept Internal Med, Botucatu, SP - Brazil
[4] Univ Estadual Paulista, UNESP, Inst Biociencias Botucatu, Dept Biostat, Botucatu, SP - Brazil
[5] Tufts Univ, Jean Mayer USDA Human Nutr Res Ctr Aging, Boston, MA 02111 - USA
[6] Konkuk Univ, Coll Biomed & Hlth Sci, Konkuk - South Korea
Número total de Afiliações: 6
Tipo de documento: Artigo Científico
Fonte: Minerva Anestesiologica; v. 79, n. 9, p. 1030-1038, SEP 2013.
Citações Web of Science: 11
Resumo

Background. The effects of anesthetics on inflammation and oxidative parameters, evaluated in patients without morbidities undergoing undergoing minor surgery, remain unknown. The present study aimed to investigate the inflammatory and oxidative stress status in adult patients undergoing elective minimally invasive surgery, using different anesthetic techniques. Methods. Thirty patients classified as ASA physical status I, who were scheduled for minor surgeries (tympanoplasty or septoplasty), were randomly allocated into two groups: balanced (BAL) anesthesia maintained with isoflurane or total intravenous anesthesia (TIVA) with propofol. Blood samples were drawn prior to the induction of anesthesia (baseline), 120 mm after the beginning of anesthesia and one day after surgery. The proinflammatory cytokine IL-6 was determined by flow cytometry; DNA oxidation was evaluated by the single cell gel electrophoresis assay, and plasma malondialdehyde (lipid peroxidation biomarker) and antioxidant status were determined through fluorometry. Results. Increased IL-6 was observed one day after surgery in both groups (P=0.0001). Malondialdehyde levels did not change among the time points assessed or between the groups (P>0.05). Whereas BAL anesthesia had no effect on acid nucleic and antioxidant status, TIVA decreased oxidized/alkylated purines (P=0.03) and increased antioxidant status (P=0.002) during anesthesia. The two groups did not differ significantly in DNA oxidation or antioxidant status (P>0.05). Conclusion. BAL anesthesia maintained with isoflurane and TIVA maintained with propofol are safe by virtue of not causing oxidative stress status in ASA physical status I patients undergoing minimally invasive surgeries. Moreover, even in minor surgeries, TIVA with propofol produces an antioxidant effect in patients. (AU)

Processo FAPESP: 06/59625-6 - Potencial toxicogenomico, citotoxico e imunotoxico dos anestesicos propofol e isoflurano em individuos submetidos a procedimentos cirurgicos.
Beneficiário:Daisy Maria Favero Salvadori
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 09/17344-9 - Perfil de expressão gênica e estresse oxidativo em pacientes submetidos à cirurgia eletiva sob anestesia geral com propofol ou isoflurano
Beneficiário:Mariana Gobbo Braz
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 10/05611-0 - Perfil de expressão gênica e estresse oxidativo em pacientes submetidos à cirurgia eletiva sob anestesia geral com propofol ou isoflurano
Beneficiário:Daisy Maria Favero Salvadori
Linha de fomento: Auxílio à Pesquisa - Regular