Kinetics of epsilon antitoxin antibodies in different strategies for active immunization of lambs against enterotoxaemia

Autor(es)

Costa, Heni F. ^[1] ; Babboni, Selene D. ^[1] ; Rodrigues, Carlos F. C. ^[2] ; Padovani, Carlos R. ^[3] ; Dutra, Iveraldo S. ^[4] ; Paulan, Silvana C. ^[4] ; Modolo, Jose R. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Paulista UNESP, Fac Med Vet & Zootecnia, Dept Higiene Vet & Saude Publ, BR-18618970 Botucatu, SP - Brazil

^[2] APTA, Unidade Pesquisa & Desenvolvimento, BR-18200970 Itapetininga, SP - Brazil

^[3] Univ Estadual Paulista Unesp, Inst Biociencias, Dept Bioestat, Botucatu, SP - Brazil

^[4] UNESP, Fac Med Vet, Dept Apoio Prod & Saude Anim, BR-16050680 Aracatuba, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Pesquisa Veterinária Brasileira; v. 33, n. 8, p. 979-982, AUG 2013.
• Citações Web of Science: 0

Resumo

Enterotoxaemia, a common disease that affects domestic small ruminants, is mainly caused by the epsilon toxin of Clostridium perfringens type D. The present study tested four distinct immunization protocols to evaluate humoral response in lambs, a progeny of non-vaccinated sheep during gestation. Twenty-four lambs were randomly allocated into four groups according to age (7, 15, 30 and 45 days), receiving the first dose of epsilon toxoid commercial vaccine against clostridiosis with booster after 30 days post vaccination. Indirect ELISA was performed after the first vaccine dose and booster to evaluate the immune response of the lambs. Results showed that for the four protocols tested all lambs presented serum title considered protective (>= 0.2UI/ml epsilon antitoxin antibodies) and also showed that the anticipation of primovaccination of lambs against enterotoxaemia conferred serum title considered protective allowing the optimization of mass vaccination of lambs. (AU)

• Processo FAPESP: 08/10957-2 - Avaliação sorológica de estratégias de imunoprofilaxia da enterotoxemia causada pela toxina épsilon do Clostridium perfringens tipo D em ovinos
• Beneficiário: José Rafael Módolo
• Modalidade de apoio: Auxílio à Pesquisa - Regular