Biosilicate (R)-gelatine bone scaffolds by the foam replica technique: development and characterization

Autor(es)

Desimone, Deborah ^[1] ; Li, Wei ^[1] ; Roether, Judith A. ^[2] ; Schubert, Dirk W. ^[2] ; Crovace, Murilo C. ^[3] ; Rodrigues, Ana Candida M. ^[3] ; Zanotto, Edgar D. ^[3] ; Boccaccini, Aldo R. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Erlangen Nurnberg, Inst Biomat, Dept Mat Sci & Engn, D-91058 Erlangen - Germany

^[2] Univ Erlangen Nurnberg, Inst Polymer Mat, Dept Mat Sci & Engn, D-91058 Erlangen - Germany

^[3] Univ Fed Sao Carlos, Dept Mat Engn, Vitreous Mat Lab, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS; v. 14, n. 4 AUG 2013.
• Citações Web of Science: 17

Resumo

The development of bioactive glass-ceramic materials has been a topic of great interest aiming at enhancing the mechanical strength of traditional bioactive scaffolds. In the present study, we test and demonstrate the use of Biosilicate (R) glass-ceramic powder to fabricate bone scaffolds by the foam replica method. Scaffolds possessing the main requirements for use in bone tissue engineering (95% porosity, 200-500 mu m pore size) were successfully produced. Gelatine coating was investigated as a simple approach to increase the mechanical competence of the scaffolds. The gelatine coating did not affect the interconnectivity of the pores and did not significantly affect the bioactivity of the Biosilicatec R scaffold. The gelatine coating significantly improved the compressive strength (i.e. 0.80 +/- 0.05MPa of coated versus 0.06 +/- 0.01MPa of uncoated scaffolds) of the Biosilicate (R) scaffold. The combination of Biosilicate (R) glass-ceramic and gelatine is attractive for producing novel scaffolds for bone tissue engineering. (AU)

• Processo FAPESP: 13/07793-6 - CEPIV - Centro de Ensino, Pesquisa e Inovação em Vidros
• Beneficiário: Edgar Dutra Zanotto
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs