Nonfunctional Overreaching Leads to Inflammation and Myostatin Upregulation in Swiss Mice

Autor(es):Mostrar menos -

Pereira, B. C. ^[1] ; Pauli, J. R. ^[2] ; de Souza, C. T. ^[3] ; Ropelle, E. R. ^[2] ; Cintra, D. E. ^[2] ; Rocha, E. M. ^[4] ; Freitas, E. C. ^[1] ; Papoti, M. ^[1] ; da Silva, L. ^[4] ; Lira, F. S. ^[3] ; da Silva, A. S. R. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Phys Educ & Sport Ribeirao Preto, BR-14049 Ribeirao Preto - Brazil

^[2] Univ Estadual Campinas, UNICAMP, Fac Sci Appl, Sport Sci Course, Campinas - Brazil

^[3] Univ Southern Santa Catarina, Hlth Sci Unit, Exercise Biochem & Physiol Lab, Postgrad Program Hlth Sci, Criciuma - Brazil

^[4] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Ophthalmol, BR-14049 Ribeirao Preto - Brazil

• Tipo de documento: Artigo Científico
• Fonte: INTERNATIONAL JOURNAL OF SPORTS MEDICINE; v. 35, n. 2, p. 139-146, FEB 2014.
• Citações Web of Science: 18

Resumo

The aims of the this study were a) to verify whether the performance decrease induced by nonfunctional overreaching (NFOR) is linked to high concentrations of cytokines in serum, skeletal muscles and liver; b) to verify muscle myostatin adaptation to NFOR; c) to verify the effects of chronic glucose supplementation on the parameters mentioned above. Mice were divided into control (C), trained (TR), overtrained (OTR) and supplemented overtrained (OTR+S). The incremental load test (ILT) and exhaustive test (ET) were used to measure performances before and after exercise protocols. 24h after ET, muscles and liver were removed and stored at -80 degrees C for subsequent measurements. Total blood was collected from decapitation for subsequent determination of cytokine concentrations. Generally, OTR and OTR+S presented higher contents of IL-6, TNF-alpha, GLUT-4 and myostatin in muscle samples compared to C and TR. Glucose supplementation attenuated the high contents of IL-6, TNF-alpha and IL-15 in liver, and of IL-6 in serum. In summary, NFOR led to low-grade chronic inflammation and myostatin upregulation. (AU)

• Processo FAPESP: 10/08239-4 - Camundongos em overtraining: relações entre a produção de citocinas pró-inflamatórias e o comprometimento das vias moleculares de sinalização da insulina
• Beneficiário: Adelino Sanchez Ramos da Silva
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 11/02652-0 - Efeitos do treinamento e do overtraining nas concentrações séricas e no conteúdo muscular de citocinas pró-inflamatórias em camundongos
• Beneficiário: Bruno Cesar Pereira
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica