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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Nonfunctional Overreaching Leads to Inflammation and Myostatin Upregulation in Swiss Mice

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Pereira, B. C. [1] ; Pauli, J. R. [2] ; de Souza, C. T. [3] ; Ropelle, E. R. [2] ; Cintra, D. E. [2] ; Rocha, E. M. [4] ; Freitas, E. C. [1] ; Papoti, M. [1] ; da Silva, L. [4] ; Lira, F. S. [3] ; da Silva, A. S. R. [1]
Total Authors: 11
[1] Univ Sao Paulo, Sch Phys Educ & Sport Ribeirao Preto, BR-14049 Ribeirao Preto - Brazil
[2] Univ Estadual Campinas, UNICAMP, Fac Sci Appl, Sport Sci Course, Campinas - Brazil
[3] Univ Southern Santa Catarina, Hlth Sci Unit, Exercise Biochem & Physiol Lab, Postgrad Program Hlth Sci, Criciuma - Brazil
[4] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Ophthalmol, BR-14049 Ribeirao Preto - Brazil
Total Affiliations: 4
Document type: Journal article
Source: INTERNATIONAL JOURNAL OF SPORTS MEDICINE; v. 35, n. 2, p. 139-146, FEB 2014.
Web of Science Citations: 18

The aims of the this study were a) to verify whether the performance decrease induced by nonfunctional overreaching (NFOR) is linked to high concentrations of cytokines in serum, skeletal muscles and liver; b) to verify muscle myostatin adaptation to NFOR; c) to verify the effects of chronic glucose supplementation on the parameters mentioned above. Mice were divided into control (C), trained (TR), overtrained (OTR) and supplemented overtrained (OTR+S). The incremental load test (ILT) and exhaustive test (ET) were used to measure performances before and after exercise protocols. 24h after ET, muscles and liver were removed and stored at -80 degrees C for subsequent measurements. Total blood was collected from decapitation for subsequent determination of cytokine concentrations. Generally, OTR and OTR+S presented higher contents of IL-6, TNF-alpha, GLUT-4 and myostatin in muscle samples compared to C and TR. Glucose supplementation attenuated the high contents of IL-6, TNF-alpha and IL-15 in liver, and of IL-6 in serum. In summary, NFOR led to low-grade chronic inflammation and myostatin upregulation. (AU)

FAPESP's process: 11/02652-0 - Effects of training and overtraining on serum concentrations and muscular content of proinflammatory cytokines in mice
Grantee:Bruno Cesar Pereira
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 10/08239-4 - Mice in overtraining: relationships between the production of pro-inflammatory cytokines and the impairment of the molecular pathways of insulin signaling
Grantee:Adelino Sanchez Ramos da Silva
Support type: Regular Research Grants