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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

High Prevalence of Skin Disorders among HTLV-1 Infected Individuals Independent of Clinical Status

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Autor(es):
Okajima, Renata [1, 2] ; Oliveira, Augusto C. P. [2] ; Smid, Jerusa [2] ; Casseb, Jorge [2, 3] ; Sanches, Jr., Jose Antonio [1]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Sch Med, Dept Dermatol, Sao Paulo - Brazil
[2] Inst Infect Dis Emilio Ribas, HTLV Outpatient Clin, Sao Paulo - Brazil
[3] Univ Sao Paulo, Sch Med, Inst Trop Med Sao Paulo, Lab Med Invest LIM56 56, Sao Paulo - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: PLoS Neglected Tropical Diseases; v. 7, n. 11 NOV 2013.
Citações Web of Science: 7
Resumo

Background: Human T-cell lymphotropic virus type 1 (HTLV-1) infection can increase the risk of developing skin disorders. This study evaluated the correlation between HTLV-1 proviral load and CD4(+) and CD8(+) T cells count among HTLV-1 infected individuals, with or without skin disorders (SD) associated with HTLV-1 infection {[}SD-HTLV-1: xerosis/ichthyosis, seborrheic dermatitis or infective dermatitis associated to HTLV-1 (IDH)]. Methods: A total of 193 HTLV-1-infected subjects underwent an interview, dermatological examination, initial HTLV-1 proviral load assay, CD4(+) and CD8(+) T cells count, and lymphproliferation assay (LPA). Results: A total of 147 patients had an abnormal skin condition; 116 (79%) of them also had SD-HTLV-1 and 21% had other dermatological diagnoses. The most prevalent SD-HTLV-1 was xerosis/acquired ichthyosis (48%), followed by seborrheic dermatitis (28%). Patients with SD-HTLV-1 were older (51 vs. 47 years), had a higher prevalence of myelopathy/tropical spastic paraparesis (HAM/TSP) (75%), and had an increased first HTLV-1 proviral load and basal LPA compared with patients without SD-HTLV-1. When excluding HAM/TSP patients, the first HTLV-1 proviral load of SD-HTLV-1 individuals remains higher than no SD-HTLV-1 patients. Conclusions: There was a high prevalence of skin disorders (76%) among HTLV-1-infected individuals, regardless of clinical status, and 60% of these diseases are considered skin disease associated with HTLV-1 infection. (AU)

Processo FAPESP: 08/56427-4 - Diversidade molecular do envelope e carga proviral do vírus linfotrópico de células T humanas tipo 2 (HTLV-2) em amotras indeterminadas pelo teste western-blot
Beneficiário:Jorge Simão do Rosário Casseb
Linha de fomento: Auxílio à Pesquisa - Regular