| Full text | |
| Author(s): |
Okajima, Renata
[1, 2]
;
Oliveira, Augusto C. P.
[2]
;
Smid, Jerusa
[2]
;
Casseb, Jorge
[2, 3]
;
Sanches, Jr., Jose Antonio
[1]
Total Authors: 5
|
| Affiliation: | [1] Univ Sao Paulo, Sch Med, Dept Dermatol, Sao Paulo - Brazil
[2] Inst Infect Dis Emilio Ribas, HTLV Outpatient Clin, Sao Paulo - Brazil
[3] Univ Sao Paulo, Sch Med, Inst Trop Med Sao Paulo, Lab Med Invest LIM56 56, Sao Paulo - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | PLoS Neglected Tropical Diseases; v. 7, n. 11 NOV 2013. |
| Web of Science Citations: | 10 |
| Abstract | |
Background: Human T-cell lymphotropic virus type 1 (HTLV-1) infection can increase the risk of developing skin disorders. This study evaluated the correlation between HTLV-1 proviral load and CD4(+) and CD8(+) T cells count among HTLV-1 infected individuals, with or without skin disorders (SD) associated with HTLV-1 infection {[}SD-HTLV-1: xerosis/ichthyosis, seborrheic dermatitis or infective dermatitis associated to HTLV-1 (IDH)]. Methods: A total of 193 HTLV-1-infected subjects underwent an interview, dermatological examination, initial HTLV-1 proviral load assay, CD4(+) and CD8(+) T cells count, and lymphproliferation assay (LPA). Results: A total of 147 patients had an abnormal skin condition; 116 (79%) of them also had SD-HTLV-1 and 21% had other dermatological diagnoses. The most prevalent SD-HTLV-1 was xerosis/acquired ichthyosis (48%), followed by seborrheic dermatitis (28%). Patients with SD-HTLV-1 were older (51 vs. 47 years), had a higher prevalence of myelopathy/tropical spastic paraparesis (HAM/TSP) (75%), and had an increased first HTLV-1 proviral load and basal LPA compared with patients without SD-HTLV-1. When excluding HAM/TSP patients, the first HTLV-1 proviral load of SD-HTLV-1 individuals remains higher than no SD-HTLV-1 patients. Conclusions: There was a high prevalence of skin disorders (76%) among HTLV-1-infected individuals, regardless of clinical status, and 60% of these diseases are considered skin disease associated with HTLV-1 infection. (AU) | |