Scaling Up of Continuous Flow Processes with Gases Using a Tube-in-Tube Reactor: Inline Titrations and Fanetizole Synthesis with Ammonia

Autor(es)

Pastre, Julio C. ^{[1, 2]} ; Browne, Duncan L. ^[2] ; O'Brien, Matthew ^[3] ; Ley, Steven V. ^[2]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Inst Quim, BR-13083970 Sao Paulo - Brazil

^[2] Univ Cambridge, Dept Chem, Whiffen Lab, Cambridge CB2 1EW - England

^[3] Keele Univ, Sch Phys & Geog Sci, Keele ST5 5BG, Staffs - England

• Tipo de documento: Artigo Científico
• Fonte: ORGANIC PROCESS RESEARCH & DEVELOPMENT; v. 17, n. 9, p. 1183-1191, SEP 2013.
• Citações Web of Science: 45

Resumo

The development of a tube-in-tube reactor based on a semipermeable polymer membrane has enabled the efficient transfer of gases into liquid flow streams. In this work we describe the scalability and throughput of this reactor when applied to ammonia gas. This is made possible by a convenient titration method to rapidly assess a wide range of parameters including the liquid and gas configuration, reactor temperatures, flow rates, and solvent polarity. These data are then employed in a scaling-up process affording alkyl thioureas and are ultimately applied to a telescoped procedure leading to the anti-inflammatory agent fanetizole on a multigram scale. (AU)

• Processo FAPESP: 12/05909-4 - Preparação da goniotalamina sob condições de reação em fluxo
• Beneficiário: Júlio Cezar Pastre
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado