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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Scaling Up of Continuous Flow Processes with Gases Using a Tube-in-Tube Reactor: Inline Titrations and Fanetizole Synthesis with Ammonia

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Author(s):
Pastre, Julio C. [1, 2] ; Browne, Duncan L. [2] ; O'Brien, Matthew [3] ; Ley, Steven V. [2]
Total Authors: 4
Affiliation:
[1] Univ Estadual Campinas, Inst Quim, BR-13083970 Sao Paulo - Brazil
[2] Univ Cambridge, Dept Chem, Whiffen Lab, Cambridge CB2 1EW - England
[3] Keele Univ, Sch Phys & Geog Sci, Keele ST5 5BG, Staffs - England
Total Affiliations: 3
Document type: Journal article
Source: ORGANIC PROCESS RESEARCH & DEVELOPMENT; v. 17, n. 9, p. 1183-1191, SEP 2013.
Web of Science Citations: 45
Abstract

The development of a tube-in-tube reactor based on a semipermeable polymer membrane has enabled the efficient transfer of gases into liquid flow streams. In this work we describe the scalability and throughput of this reactor when applied to ammonia gas. This is made possible by a convenient titration method to rapidly assess a wide range of parameters including the liquid and gas configuration, reactor temperatures, flow rates, and solvent polarity. These data are then employed in a scaling-up process affording alkyl thioureas and are ultimately applied to a telescoped procedure leading to the anti-inflammatory agent fanetizole on a multigram scale. (AU)

FAPESP's process: 12/05909-4 - Preparation of goniothalamin under flow reaction conditions
Grantee:Júlio Cezar Pastre
Support Opportunities: Scholarships abroad - Research Internship - Post-doctor