| Texto completo | |
| Autor(es): |
Murray, Philip R. D.
[1]
;
Browne, Duncan L.
[1]
;
Pastre, Julio C.
[2, 1]
;
Butters, Chris
[3]
;
Guthrie, Duncan
[3]
;
Ley, Steven V.
[1]
Número total de Autores: 6
|
| Afiliação do(s) autor(es): | [1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW - England
[2] Univ Estadual Campinas, Inst Quim, BR-13083970 Sao Paulo - Brazil
[3] Vapourtec Ltd, Pk Farm Business Ctr, Bury St Edmunds IP28 6TS, Suffolk - England
Número total de Afiliações: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | ORGANIC PROCESS RESEARCH & DEVELOPMENT; v. 17, n. 9, p. 1192-1208, SEP 2013. |
| Citações Web of Science: | 79 |
| Resumo | |
A new enabling technology for the pumping of organometallic reagents such as n-butyllithium, Grignard reagents, and DIBAL-H is reported, which utilises a newly developed, chemically resistant, peristaltic pumping system. Several representative examples of its use in common transformations using these reagents, including metal-halogen exchange, addition, addition-elimination, conjugate addition, and partial reduction, are reported along with examples of telescoping of the anionic reaction products. This Platform allows for truly continuous pumping of these highly reactive substances (and examples are demonstrated over periods of several hours) to generate multigram quantities of products. This work culminates in an approach to the telescoped synthesis of (E/Z)-tamoxifen using continuous-flow organometallic reagent-mediated transformations. (AU) | |
| Processo FAPESP: | 12/05909-4 - Preparação da goniotalamina sob condições de reação em fluxo |
| Beneficiário: | Júlio Cezar Pastre |
| Modalidade de apoio: | Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado |