Angiogenic factors and uterine Doppler velocimetry in early- and late- onset preeclampsia

Autor(es)

Tobinaga, Clarissa M. ^[1] ; Torloni, Maria R. ^[1] ; Gueuvoghlanian-Silva, Barbara Y. ^[1] ; Pendeloski, Karen P. T. ^[1] ; Akita, Patricia A. ^[1] ; Sass, Nelson ^[1] ; Daher, Silvia ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Dept Obstet, BR-04039032 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA; v. 93, n. 5, p. 469-476, MAY 2014.
• Citações Web of Science: 12

Resumo

ObjectiveTo assess correlations between maternal serum levels of pro- and anti-angiogenic factors with uterine perfusion in women with early- compared with late-onset preeclampsia, and in healthy pregnant women. DesignCase-control study. SettingAntenatal care clinic located within a hospital (SAo Bernardo do Campo, Brazil). PopulationWe enrolled 54 preeclamptic and 54 healthy control women who were coming for routine ultrasound at 28-36weeks' gestation. MethodsAll participants had uterine artery and umbilical Doppler studies and a blood sample to assess maternal serum levels of soluble fms-like tyrosine kinase-1, soluble endoglin, adiponectin and plasminogen activator inhibitor-1. All angiogenic factors were measured using enzyme-linked immunosorbent assay. Main outcome measuresLevels of pro- and anti-angiogenic factors in maternal serum, and uterine artery Doppler findings. ResultsConcentrations of soluble fms-like tyrosine kinase-1 and soluble endoglin were significantly higher in preeclamptic than control women (p<0.0001 and p<0.0001, respectively), especially in those with early-onset (<34weeks) preeclampsia. These two anti-angiogenic mediators were significantly correlated with increased uterine artery Doppler in the preeclamptic women. Plasminogen activator inhibitor-1 levels were significantly higher in preeclampsia (p=0.03) but unrelated to uterine artery resistance. Adiponectin levels were similar in cases and controls, independent of body mass index and unrelated to uterine artery resistance. ConclusionPreeclamptic patients have increased soluble fms-like tyrosine kinase-1 and soluble endoglin serum levels and this increase is directly correlated with uterine artery resistance, especially in those with early-onset preeclampsia. (AU)

• Processo FAPESP: 10/08082-8 - Marcadores de angiogênese em pacientes com pre-eclâmpsia
• Beneficiário: Patricia Akie Akita
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 09/54729-6 - Marcadores de angiogênese e dopplervelocimetria útero-placentária em pacientes com pré-eclâmpsia
• Beneficiário: Silvia Daher
• Modalidade de apoio: Auxílio à Pesquisa - Regular