Bronchodilator response as a hallmark of uncontrolled asthma: a randomised clinical trial

Autor(es)

Godoy Fernandes, Ana Luisa ^[1] ; Amorim, Maria Marta ^[1] ; Caetano, Lilian Ballini ^[1] ; Dracoulakis, Samir ^[1] ; Ramalho Araruna, Alexandre Augusto ^[1] ; Faresin, Sonia Maria ^[1] ; Santoro, Ilka Lopes ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Escola Paulista Med, Div Resp, BR-04023062 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF ASTHMA; v. 51, n. 4, p. 405-410, MAY 2014.
• Citações Web of Science: 2

Resumo

Introduction: The goal of this study is to determine whether bronchodilator (BD) response can be used as a reliable measure of asthma control by analyzing the effects of a short course of oral corticosteroids (OC) or placebo (P) on spirometry, sputum cytology and BD response in controlled asthma patients scoring less than 1.5 on the ACQ5. Methods: Seventy patients with moderate to severe asthma who were undergoing combination therapy and were considered to be controlled based on ACQ5 scores, but who exhibited persistent positive BD response, were randomly assigned to two groups, one receiving OC and the other P. Patients were evaluated before and after 2 weeks of treatment. Intervention response (comparison of FEV1 before and after OC or P treatment) was used as a measure of intervention efficacy, with values equal to or greater than 200 mL considered positive. Results: Patients who received OC showed significant improvement in FEV1, and no longer exhibited a positive BD response. Those in the P group showed no change. In addition, sputum eosinophil counts significantly decreased in the OC group. Conclusions: BD response can be used as a reliable measure of asthma control. This study suggests that ACQ5 scores alone are not sufficient to fully assess asthma control, and that BD response should be included as an essential measurement in any algorithm of asthma control evaluation. (AU)

• Processo FAPESP: 05/04714-1 - Avaliação funcional, tomográfica e inflamatória das vias aéreas como ferramenta para controle da terapêutica antiinflamatória em asmáticos moderados e graves
• Beneficiário: Ana Luisa Godoy Fernandes
• Modalidade de apoio: Auxílio à Pesquisa - Regular