Effect of Charge Regulation and Ion-Dipole Interactions on the Selectivity of Protein-Nanoparticle Binding

Autor(es)

Barroso da Silva, Fernando Luis ^[1] ; Bostrom, Mathias ^{[2, 3]} ; Persson, Clas ^{[2, 3, 4]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Pharmaceut Sci Ribeirao Preto, Dept Phys & Chem, BR-14040903 Ribeirao Preto, SP - Brazil

^[2] Royal Inst Technol, Dept Mat Sci & Engn, SE-10044 Stockholm - Sweden

^[3] Univ Oslo, Ctr Mat Sci & Nanotechnol, NO-0316 Oslo - Norway

^[4] Univ Oslo, Dept Phys, NO-0316 Oslo - Norway

• Tipo de documento: Artigo Científico
• Fonte: Langmuir; v. 30, n. 14, p. 4078-4083, APR 15 2014.
• Citações Web of Science: 20

Resumo

We investigate the role of different mesoscopic interactions (Coulomb, charge regulation, and ion-dipole ``surface patch{''} effects) on the binding of bovine serum albumin (BSA) and beta-lactoglobulin (BLG) to a cationic gold nanoparticle (TTMA+). The results demonstrate that the charge-regulation mechanism plays a vital role for selectivity of protein-nanoparticle complexation at low salt concentration. At slightly higher ionic strengths, charge-dipole effects are the dominating driving force. Thus, very small variations in salt concentration strongly influence the origin of complexation. (AU)

• Processo FAPESP: 10/50425-0 - Mecanismos moleculars fundamentais responsaveis pela complexacao de proteinas. de parametros fisico-quimicos as aplicacoes em tecnologia de alimentos e farmaceutica.
• Beneficiário: Fernando Luis Barroso da Silva
• Modalidade de apoio: Auxílio à Pesquisa - Regular