| Texto completo | |
| Autor(es): |
Borbely, Alexandre U.
[1]
;
Daher, Silvia
[2]
;
Ishigai, Marcia M.
[3]
;
Mattar, Rosiane
[2]
;
Sun, Sue Y.
[2]
;
Knoefler, Martin
[4]
;
Bevilacqua, Estela
[1]
;
Oliveira, Sergio F.
[1]
Número total de Autores: 8
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Inst Biomed Sci, Dept Cell & Dev Biol, BR-05508900 Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Dept Obstet, Sao Paulo - Brazil
[3] Univ Fed Sao Paulo, Dept Pathol, Paulista Med Sch, Sao Paulo - Brazil
[4] Med Univ Vienna, Reprod Biol Unit, Dept Obstet & Fetal Maternal Med, Vienna - Austria
Número total de Afiliações: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Histopathology; v. 64, n. 5, p. 616-625, APR 2014. |
| Citações Web of Science: | 7 |
| Resumo | |
Aims Decorin and biglycan are members of the small leucine-rich proteoglycan family, and constituents of both the extracellular matrix (ECM) and the cell surface. They are recognized as important factors in the control of proliferation, migration and invasion invivo and invitro. In this study, the localization patterns of decorin and biglycan were determined in healthy placentas and in highly invasive placental pathologies. Methods and results The study included immunolocalization of decorin and biglycan in samples of first-trimester and term placentas, placenta accreta, invasive mole, and choriocarcinoma. Extravillous cytotrophoblast (EVT) cells were positive for both proteoglycans in all pathologies and in first-trimester placentas, although not in term placentas. Biglycan was immunolocalized in the ECM of all healthy and pathological placentas, whereas decorin was observed only in term placenta ECM. Conclusions The expression of both proteoglycans was cell-specific and gestation time-dependent in healthy placentas, and was associated with invasive EVT cells in pathological placentas. In view of the biological properties of these molecules, it is possible that the biglycan pattern found here is intrinsically implicated in the invasive activity of EVT cells in both healthy and disordered placentas. (AU) | |
| Processo FAPESP: | 01/09019-9 - Estudo morfológico ultra-estrutural da citoarquitetura de decídua mesometrial de camundongos: caracterização in vivo e in vitro |
| Beneficiário: | Alex Kors Vidsiunas |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |