Aerobic Training Prevents Dexamethasone-Induced Peripheral Insulin Resistance

Autor(es):Mostrar menos -

Dionisio, T. J. ^{[1, 2]} ; Louzada, J. C. A. ^[3] ; Viscelli, B. A. ^[3] ; Dionisio, E. J. ^[3] ; Martuscelli, A. M. ^[3] ; Barel, M. ^[3] ; Perez, O. A. B. ^[3] ; Bosqueiro, J. R. ^[3] ; Brozoski, D. T. ^[1] ; Santos, C. F. ^[1] ; Amaral, S. L. ^{[2, 3]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Bauru Sch Dent, Dept Biol Sci, Bauru - Brazil

^[2] Fed Univ Sao Carlos UFSCar, Dept Physiol Sci, Sao Carlos, SP - Brazil

^[3] UNESP Sao Paulo State Univ, Dept Phys Educ, Bauru, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Hormone and Metabolic Research; v. 46, n. 7, p. 484-489, JUN 2014.
• Citações Web of Science: 11

Resumo

This study investigated how proteins of the insulin signaling cascade could modulate insulin resistance after dexamethasone (Dexa) treatment and aerobic training. Rats were distributed into 4 groups: sedentary control (SC), sedentary + Dexa (SD), trained control (TC), and trained + Dexa (TD), and underwent aerobic training for 70 days or remained sedentary. Dexa was administered during the last 10 days (1 mg center dot kg(-1) per day i.p.). After 70 days, an intraperitoneal glucose tolerance test (ipGTT) was performed. Protein levels of IRS-1, AKT, and PKC-alpha in the tibialis anterior (TA) muscle were identified using Western blots. Dexa treatment increased blood glucose and the area under the curve (AUC) of ipGTT. Training attenuated the hyperglycemia and the AUC induced by Dexa. Dexa reduced IRS-1 (-16 %) and AKT (-43 %) protein level with no changes in PKC-a levels. Moreover, these effects on IRS-1 and AKT protein level were prevented in trained animals. These results show for the first time that aerobic exercise prevented reductions of IRS-1 and AKT level induced by Dexa in the TA muscle, suggesting that aerobic exercise is a good strategy to prevent Dexa-induced peripheral insulin resistance. (AU)

• Processo FAPESP: 08/00821-6 - Efeitos do Exercício Físico nas vias de sinalização do transporte de glicose independentes de insulina em ratos tratados com Dexametasona.
• Beneficiário: Juliana Cavalcante de Andrade Louzada
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 06/51935-6 - Efeitos preventivos do exercicio fisico aerobio na musculatura esqueletica e cardiaca de animais tratados com dexametasona.
• Beneficiário: Otávio André Brogin Perez
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 07/59770-9 - Papel do exercicio fisico como prevencao dos efeitos adversos do tratamento com dexametasona no metabolismo e na musculatura esqueletica.
• Beneficiário: Sandra Lia do Amaral Cardoso
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 06/51936-2 - Efeitos preventivos do exercicio fisico aerobio na musculatura esqueletica e cardiaca de animais tratados com dexametasona.
• Beneficiário: Matheus Barel
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica