Effect of hormone replacement therapy on cardiac autonomic modulation

Autor(es)

Perseguini, Natalia Maria ^[1] ; de Medeiros Takahashi, Anielle Cristhine ^[2] ; Milan, Juliana Cristina ^[1] ; dos Santos, Patricia Rehder ^[1] ; Camargo Neves, Valeria Ferreira ^[1] ; Borghi-Silva, Audrey ^[3] ; Silva, Ester ^[1] ; Montano, Nicola ^[4] ; Porta, Alberto ^[5] ; Catai, Aparecida Maria ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Carlos, Cardiovasc Phys Therapy Lab, Nucleus Res Phys Exercise NUPEF, Dept Phys Therapy, UFSCar, BR-13565905 Sao Carlos, SP - Brazil

^[2] Univ Fed Sao Carlos, Geriatr Phys Therapy Lab, Dept Phys Therapy, UFSCar, BR-13565905 Sao Carlos, SP - Brazil

^[3] Univ Fed Sao Carlos, Cardiopulm Phys Therapy Lab, Nucleus Res Phys Exercise NUPEF, Dept Phys Therapy, UFSCar, BR-13565905 Sao Carlos, SP - Brazil

^[4] Univ Milan, Dept Clin Sci L Sacco, L Sacco Hosp, Milan - Italy

^[5] Univ Milan, Galeazzi Orthopaed Inst, Dept Biomed Sci Hlth, Milan - Italy

• Tipo de documento: Artigo Científico
• Fonte: CLINICAL AUTONOMIC RESEARCH; v. 24, n. 2, p. 63-70, APR 2014.
• Citações Web of Science: 7

Resumo

Objective To investigate the effects of hormone replacement therapy (HRT) on heart rate variability (HRV) in healthy postmenopausal women. Methods Two groups were evaluated: group 1 (G1): 20 women not undergoing HRT (60 +/- 5.89 years), group 2 (G2): 20 women undergoing HRT (59 +/- 5.70 years). The HRTs involved were either conjugated equine estrogen with or without medroxyprogesterone, synthetic estrogen hormone, estradiol associated with norethisterone acetate or isoflavonoids. Electrocardiogram was recorded in the supine position for 10 min. Spectral analysis included low and high frequencies in absolute (LF and HF) and normalized units (LFnu and HFnu), which are predominantly cardiac sympathetic modulation (CSM) and cardiac vagal modulation (CVM) indicators, respectively. The LF/HF ratio was also calculated. Symbolic analysis involved the following indexes: 0V % (CSM indicator), 1V % (CSM and CVM indicators), 2LV % (predominantly CVM indicator) and 2UV % (CVM indicator). Shannon and conditional entropies were also calculated. Results Spectral analysis demonstrated that HRT affected HRV. LF, LFnu and LF/HF ratio were higher (showing increased CSM), while HFnu was lower (representing decreased CVM) in G2 than in G1. Correlations between complexity indices and HFnu were significant and positive only in G1. Interpretation Women undergoing HRT presented higher CSM and lower CVM than those who were not. Moreover, the expected positive relationship between CVM and complexity of HRV was found only in control group, thus indicating that CVM in women under therapy drop below a minimal value necessary to the association to become apparent, suggesting an unfavorable cardiac autonomic modulation in spite of HRT. (AU)

• Processo FAPESP: 10/52703-7 - Estudo da modulacao autonomica cardiaca no processo de envelhecimento e suas relacoes com a terapia de reposicao hormonal,proteina c-reativa e comprimento de telomeros.
• Beneficiário: Natália Maria Perseguini
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 10/52070-4 - Novas técnicas para avaliação das alterações das oscilações cardiovasculares com o envelhecimento
• Beneficiário: Aparecida Maria Catai
• Modalidade de apoio: Auxílio à Pesquisa - Regular