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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effect of hormone replacement therapy on cardiac autonomic modulation

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Author(s):
Perseguini, Natalia Maria [1] ; de Medeiros Takahashi, Anielle Cristhine [2] ; Milan, Juliana Cristina [1] ; dos Santos, Patricia Rehder [1] ; Camargo Neves, Valeria Ferreira [1] ; Borghi-Silva, Audrey [3] ; Silva, Ester [1] ; Montano, Nicola [4] ; Porta, Alberto [5] ; Catai, Aparecida Maria [1]
Total Authors: 10
Affiliation:
[1] Univ Fed Sao Carlos, Cardiovasc Phys Therapy Lab, Nucleus Res Phys Exercise NUPEF, Dept Phys Therapy, UFSCar, BR-13565905 Sao Carlos, SP - Brazil
[2] Univ Fed Sao Carlos, Geriatr Phys Therapy Lab, Dept Phys Therapy, UFSCar, BR-13565905 Sao Carlos, SP - Brazil
[3] Univ Fed Sao Carlos, Cardiopulm Phys Therapy Lab, Nucleus Res Phys Exercise NUPEF, Dept Phys Therapy, UFSCar, BR-13565905 Sao Carlos, SP - Brazil
[4] Univ Milan, Dept Clin Sci L Sacco, L Sacco Hosp, Milan - Italy
[5] Univ Milan, Galeazzi Orthopaed Inst, Dept Biomed Sci Hlth, Milan - Italy
Total Affiliations: 5
Document type: Journal article
Source: CLINICAL AUTONOMIC RESEARCH; v. 24, n. 2, p. 63-70, APR 2014.
Web of Science Citations: 7
Abstract

Objective To investigate the effects of hormone replacement therapy (HRT) on heart rate variability (HRV) in healthy postmenopausal women. Methods Two groups were evaluated: group 1 (G1): 20 women not undergoing HRT (60 +/- 5.89 years), group 2 (G2): 20 women undergoing HRT (59 +/- 5.70 years). The HRTs involved were either conjugated equine estrogen with or without medroxyprogesterone, synthetic estrogen hormone, estradiol associated with norethisterone acetate or isoflavonoids. Electrocardiogram was recorded in the supine position for 10 min. Spectral analysis included low and high frequencies in absolute (LF and HF) and normalized units (LFnu and HFnu), which are predominantly cardiac sympathetic modulation (CSM) and cardiac vagal modulation (CVM) indicators, respectively. The LF/HF ratio was also calculated. Symbolic analysis involved the following indexes: 0V % (CSM indicator), 1V % (CSM and CVM indicators), 2LV % (predominantly CVM indicator) and 2UV % (CVM indicator). Shannon and conditional entropies were also calculated. Results Spectral analysis demonstrated that HRT affected HRV. LF, LFnu and LF/HF ratio were higher (showing increased CSM), while HFnu was lower (representing decreased CVM) in G2 than in G1. Correlations between complexity indices and HFnu were significant and positive only in G1. Interpretation Women undergoing HRT presented higher CSM and lower CVM than those who were not. Moreover, the expected positive relationship between CVM and complexity of HRV was found only in control group, thus indicating that CVM in women under therapy drop below a minimal value necessary to the association to become apparent, suggesting an unfavorable cardiac autonomic modulation in spite of HRT. (AU)

FAPESP's process: 10/52070-4 - New approaches for evaluation of cardiovascular oscillations changes with aging
Grantee:Aparecida Maria Catai
Support Opportunities: Regular Research Grants