Allelic frequencies of six polymorphic markers for risk of prostate cancer

Autor(es)

M.L. Ribeiro ^[1] ; A. Santos ^[2] ; A.B. Carvalho-Salles ^[3] ; C. Hackel

Afiliação do(s) autor(es)

^[1] Universidade Estadual de Campinas. Faculdade de Ciências Médicas. Centro de Biologia Molecular e Engenharia Genética

^[2] Universidade Estadual de Campinas. Faculdade de Ciências Médicas. Centro de Biologia Molecular e Engenharia Genética

^[3] Hemocentro - Brasil

• Tipo de documento: Artigo Científico
• Fonte: Brazilian Journal of Medical and Biological Research; v. 35, n. 2, p. 205-213, 2002-02-00.

Resumo

The aim of the present study was to evaluate the distribution of polymorphisms for the androgen receptor (AR) (CAG, StuI, GGN), SRD5A2 (Ala49Thr, Val89Leu) and CYP17 (MspA1) genes that are considered to be relevant for risk of prostate cancer. We studied 200 individuals from two cities in the State of São Paulo, by PCR, PCR-RFLP and ASOH techniques. The allelic frequencies of the autosomal markers and the StuI polymorphism of the AR gene were very similar to those described in most North American and European populations. In relation to the CAG and GGN number of repeats, the study subjects had smaller repeat lengths (mean of 20.65 and 22.38, respectively) than those described in North American, European and Chinese populations. In the present study, 30.5% of the individuals had less than 22 CAG repeats and 45.5% had less than 23 GGN repeats. When both repeat lengths are considered jointly, this Brazilian population is remarkably different from the others. Further studies on prostate cancer patients need to be conducted to assess the significance of these markers in the Brazilian population. (AU)

• Processo FAPESP: 00/04251-8 - Identificação de genes candidatos relacionados a tumores testiculares e à infertilidade masculina, a partir das sequências expressas do Projeto Genoma Humano do Câncer
• Beneficiário: Andrey dos Santos
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica