Screening of antibacterial extracts from plants native to the Brazilian Amazon Rain Forest and Atlantic Forest

Autor(es)

I.B. Suffredini ^[1] ; H.S. Sader ^[2] ; A.G. Gonçalves ^[3] ; A.O. Reis ^[4] ; A.C. Gales ^[5] ; A.D. Varella ^[6] ; R.N. Younes ^[7]

Afiliação do(s) autor(es)

^[1] Universidade Paulista. Laboratório de Extração - Brasil

^[2] Universidade Federal de São Paulo. Laboratório Especial de Microbiologia Clínica - Brasil

^[3] Universidade Federal do Maranhão. Centro de Ciências Biológicas e da Saúde - Brasil

^[4] Universidade Federal de São Paulo. Laboratório Especial de Microbiologia Clínica - Brasil

^[5] Universidade Federal de São Paulo. Laboratório Especial de Microbiologia Clínica - Brasil

^[6] Universidade Paulista. Laboratório de Extração - Brasil

^[7] Universidade Paulista. Laboratório de Extração - Brasil

• Tipo de documento: Artigo Científico
• Fonte: Brazilian Journal of Medical and Biological Research; v. 37, n. 3, p. 379-384, 2004-03-00.

Resumo

More than 20% of the world's biodiversity is located in Brazilian forests and only a few plant extracts have been evaluated for potential antibacterial activity. In the present study, 705 organic and aqueous extracts of plants obtained from different Amazon Rain Forest and Atlantic Forest plants were screened for antibacterial activity at 100 µg/ml, using a microdilution broth assay against Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa and Escherichia coli. One extract, VO581, was active against S. aureus (minimum inhibitory concentration (MIC) = 140 µg/ml and minimal bactericidal concentration (MBC) = 160 µg/ml, organic extract obtained from stems) and two extracts were active against E. faecalis, SM053 (MIC = 80 µg/ml and MBC = 90 µg/ml, organic extract obtained from aerial parts), and MY841 (MIC = 30 µg/ml and MBC = 50 µg/ml, organic extract obtained from stems). The most active fractions are being fractionated to identify their active substances. Higher concentrations of other extracts are currently being evaluated against the same microorganisms. (AU)

• Processo FAPESP: 99/05904-6 - Avaliação da resposta citotóxica, antitumoral e antimicrobiana in vitro e in vivo de extratos de algumas espécies vegetais pertencentes às famílias Apocynaceae, Annonaceae, Clusiaceae e Euphorbiaceae
• Beneficiário: Riad Naim Younes
• Modalidade de apoio: Auxílio à Pesquisa - Regular