Roles of mitogen-activated protein kinases and angiotensin II in renal development

Autor(es)

A.P.C. Balbi ^[1] ; H.D.C. Francescato ^[2] ; E.C.S. Marin ^[3] ; R.S. Costa ^[4] ; T.M. Coimbra ^[5]

Afiliação do(s) autor(es)

^[1] Universidade de São Paulo. Departamento de Fisiologia

^[2] Universidade de São Paulo. Departamento de Fisiologia

^[3] Universidade de São Paulo. Departamento de Fisiologia

^[4] Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Patologia - Brasil

^[5] Universidade de São Paulo. Departamento de Fisiologia

• Tipo de documento: Artigo Científico
• Fonte: Brazilian Journal of Medical and Biological Research; v. 42, n. 1, p. 38-43, 2009-01-00.
• Assunto(s): Angiotensinas

Resumo

Experimental and clinical evidence suggests that angiotensin II (AII) participates in renal development. Renal AII content is several-fold higher in newborn rats and mice than in adult animals. AII receptors are also expressed in higher amounts in the kidneys of newborn rats. The kidneys of fetuses whose mother received a type 1 AII receptor (AT1) antagonist during gestation present several morphological alterations. Mutations in genes that encode components of the renin-angiotensin system are associated with autosomal recessive renal tubular dysgenesis. Morphological changes were detected in the kidneys of 3-week-old angiotensin-deficient mice. Mitogen-activated protein kinases (MAPKs) are important mediators that transduce extracellular stimuli to intracellular responses. The MAPK family comprises three major subgroups, namely extracellular signal-regulated protein kinase (ERK), c-jun N-terminal kinases (JNK), and p38 MAPK (p38). Important events in renal growth during nephrogenesis such as cellular proliferation and differentiation accompanied by apoptosis on a large scale can be mediated by MAPK pathways. A decrease in glomerulus number was observed in embryos cultured for 48 and 120 h with ERK or p38 inhibitors. Many effects of AII are mediated by MAPK pathways. Treatment with losartan during lactation provoked changes in renal function and structure associated with alterations in AT1 and type 2 AII (AT2) receptors and p-JNK and p-p38 expression in the kidney. Several studies have shown that AII and MAPKs play an important role in renal development. However, the relationship between the effects of AII and MAPK activation on renal development is still unclear. (AU)

• Processo FAPESP: 07/55816-4 - Estudo das alteracoes de funcao e estrutura renal provocadas em ratos pela exposicao ao losartan durante o periodo de lactacao: efeito do tempol.
• Beneficiário: Evelyn Cristina Santana Marin
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 06/57015-6 - Efeito da inibicao da map quinase p38 na evolucao da lesao renal provocada pelo glicerol.
• Beneficiário: Terezila Machado Coimbra
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 02/04457-0 - Participação da angiotensina II e map quinases (mitogenic activated protein kinase) no desenvolvimento renal pós natal de ratas Wistar
• Beneficiário: Ana Paula Coelho Balbi
• Modalidade de apoio: Bolsas no Brasil - Doutorado