Duration-controlled swimming exercise training induces cardiac hypertrophy in mice

Autor(es)

F.S. Evangelista ^[1] ; P.C. Brum ^[2] ; J.E. Krieger ^[3]

Afiliação do(s) autor(es)

^[1] Universidade de São Paulo. Faculdade de Medicina. Instituto do Coração

^[2] Universidade de São Paulo. Escola de Educação Física e Esportes - Brasil

^[3] Universidade de São Paulo. Faculdade de Medicina. Instituto do Coração

• Tipo de documento: Artigo Científico
• Fonte: Brazilian Journal of Medical and Biological Research; v. 36, n. 12, p. 1751-1759, 2003-12-00.

Resumo

Exercise training associated with robust conditioning can be useful for the study of molecular mechanisms underlying exercise-induced cardiac hypertrophy. A swimming apparatus is described to control training regimens in terms of duration, load, and frequency of exercise. Mice were submitted to 60- vs 90-min session/day, once vs twice a day, with 2 or 4% of the weight of the mouse or no workload attached to the tail, for 4 vs 6 weeks of exercise training. Blood pressure was unchanged in all groups while resting heart rate decreased in the trained groups (8-18%). Skeletal muscle citrate synthase activity, measured spectrophotometrically, increased (45-58%) only as a result of duration and frequency-controlled exercise training, indicating that endurance conditioning was obtained. In groups which received duration and endurance conditioning, cardiac weight (14-25%) and myocyte dimension (13-20%) increased. The best conditioning protocol to promote physiological hypertrophy, our primary goal in the present study, was 90 min, twice a day, 5 days a week for 4 weeks with no overload attached to the body. Thus, duration- and frequency-controlled exercise training in mice induces a significant conditioning response qualitatively similar to that observed in humans. (AU)

• Processo FAPESP: 99/01881-1 - Padronização de um protocolo de treinamento físico com natação para desenvolvimento de hipertrofia cardíaca em camundongos
• Beneficiário: Fabiana de Sant'Anna Evangelista
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 01/00009-0 - Estudo integrado da hipertensão arterial: caracterização molecular e funcional do sistema cardiovascular
• Beneficiário: Eduardo Moacyr Krieger
• Modalidade de apoio: Auxílio à Pesquisa - Temático