Relationship of short tandem repeats flanking leptin-melanocortin pathway genes with anthropometric profile and leptinemia in Brazilian individuals

Autor(es)

Hinuy, Hamilton M. ; Arazi, Simone S. ^[1] ; Hirata, Mario H. ; Sampaio, Marcelo F. ^[1] ; Armaganijan, Dikran ^[1] ; Cavalli, Selma A. ^[2] ; Hirata, Rosario D. C. ^[3]

Afiliação do(s) autor(es)

^[1] IDPC, Sao Paulo - Brazil

^[2] Life Technol, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Anal Clin & Toxicol, BR-05508900 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Arquivos Brasileiros de Endocrinologia e Metabologia; v. 56, n. 1, p. 47-53, FEB 2012.
• Citações Web of Science: 1

Resumo

Objective: To investigate the relationship of short tandem repeats (STR) near genes involved in the leptin-melanocortin pathway with body mass index (BMI) and leptinemia. Subjects and methods: Anthropometric variables and leptinemia were measured in 100 obese and 110 non-obese individuals. D1S200, D2S1788, DS11912, and D18S858 loci were analyzed by PCR and high-resolution electrophoresis. Results: Overall STR allele frequencies were similar between the obese and non-obese group (p > 0.05). Individual alleles D1S200 (17), D11S912 (43), D18S858 (11/12) were associated with obesity (p < 0.05). Individuals carrying these alleles showed higher BMI than non-carriers (p < 0.05). Moreover, a relationship between D18S858 11/12 alleles and increased waist circumference was found (p = 0.040). On the other hand, leptinemia was not influenced by the studied STRs (p > 0.05). Conclusions: D1S200, D11S912, and D18S858 loci are associated with increased BMI and risk for obesity in this sample. Arq Bras Endocrinol Metab. 2012;56(1):47-53 (AU)

• Processo FAPESP: 01/10708-3 - Estudo de marcadores geneticos associados com a obesidade.
• Beneficiário: Rosario Dominguez Crespo Hirata
• Modalidade de apoio: Auxílio à Pesquisa - Regular